A modified orthogonal-distance ray-tracer method applied to dual rotation PET systems.

A new projector, Orthogonal-Distance Ray-tracer Varying-Full Width at Half Maximum (OD-RT-VF), was developed to model a shift-variant elliptical point-spread function (PSF) response to improve the image quality of a preclinical dual-rotation PET system. Approach: The OD-RT-VF projector models different FWHM values of the PSF in multiple directions, using half-height and half-width tube-of-response (ToR) values. The OD-RT-VF method's performance was evaluated against the original OD-RT method and a ToR model with constant response.

Newly Proposed Dose of Daclatasvir to Prevent Lethal SARS-CoV-2 Infection in Human Transgenic ACE-2 Mice.

Coronavirus disease 2019 (COVID-19) still causes death in elderly and immunocompromised individuals, for whom the sustainability of the vaccine response may be limited. Antiviral treatments, such as remdesivir or molnupiravir, have demonstrated limited clinical efficacy. Nirmatrelvir, an acute respiratory syndrome coronavirus 2 (SARS-CoV-2) major protease inhibitor, is clinically effective but has been associated with viral rebound and antiviral resistance.

-Derived β-Glucan Capsules as a Delivery System for DNA Vaccines.

Background/objectives: DNA vaccines are rapidly produced and adaptable to different pathogens, but they face considerable challenges regarding stability and delivery to the cellular target. Thus, effective delivery methods are essential for the success of these vaccines. Here, we evaluated the efficacy of capsules derived from the cell wall of the yeast as a delivery system for DNA vaccines.

Longitudinal Immunological Analysis of Portuguese Healthcare Workers Across the COVID-19 Pandemic Reveals Differences in the Humoral Immune Response to Vaccines.

A vaccination programme against severe acute respiratory syndrome coronavirus 2 was initiated in Portugal in December 2020. In this study, we report the findings of a prospective cohort study implemented with the objective of monitoring antibody production in response to COVID-19 vaccination. The humoral immune response to vaccination was followed up using blood samples collected from 191 healthcare workers.

Upcity: Addressing Urban Problems Through an Integrated System.

Current technologies could potentially solve many of the urban problems in today's cities. Many cities already possess cameras, drones, thermometers, pollution air gauges, and other sensors. However, most of these have been designated for use in individual domains within City Hall, creating a maze of individual data domains that cannot connect to each other.