Publications by authors named "A B Shreya"
Article Synopsis
- Asenapine maleate (ASPM) is a second-generation antipsychotic approved for adult schizophrenia and bipolar disorder but suffers from low oral bioavailability (<2%) due to extensive first-pass metabolism in the liver.
- To improve ASPM's absorption, researchers developed nanoformulations using ligands like RGD and peptide dendrimers to target the intestinal lymphatic system.
- Various techniques, including solid phase peptide synthesis and high-performance chromatography, were used to create and characterize liposomal formulations, and in vitro and in vivo studies were conducted to assess their effectiveness and pharmacokinetics in rats.
Background And Aims: Anxiety plays a distressing role in cardiothoracic operations. It may trigger hemodynamic instability, increased morbidity, and very crucially, postoperative pain and analgesic use. Our aim is to look at the association between anxiety, postoperative pain, and analgesic use.
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- - Perforated peptic ulcers are a significant surgical emergency in India, leading to high morbidity and mortality rates, with this study analyzing 500 cases to identify risk factors.
- - The patient population was predominantly male (96%), with a mean age of 46.5 years; complications included prolonged intubation and a re-exploration rate of 6.2%.
- - Key predictors of post-operative issues and mortality include being over 60 years old, having comorbid conditions, presenting in shock, and having a perforation size larger than 1 cm.
There is widespread agreement that clinical trials should be registered in a public registry, preferably before the trial commences. It is also important that details of each trial in the public record are complete and accurate. In this study, we examined the trial sites and ethics committee (EC) data for 1359 recent Phase 2 or Phase 3 interventional trials registered with Clinical Trials Registry-India (CTRI), to identify categories of problems that prevent the clear identification of which EC approved a given site.
View Article and Find Full Text PDFSensing surface topography, an upsurge of signaling biomolecules, and upholding cellular homeostasis are the rate-limiting spatio-temporal events in microbial attachment and biofilm formation. Initially, a set of highly specialized proteins, . conditioning protein, directs the irreversible attachment of the microbes.
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