Identification of differentially expressed gene modules in heterogeneous diseases.

Motivation: Identification of differentially expressed genes is necessary for unraveling disease pathogenesis. This task is complicated by the fact that many diseases are heterogeneous at the molecular level and samples representing distinct disease subtypes may demonstrate different patterns of dysregulation. Biclustering methods are capable of identifying genes that follow a similar expression pattern only in a subset of samples and hence can consider disease heterogeneity.

[Myelochondroplasty of bone cavities and defects of the jaw bones].

A new transplant is designed which consists of an autologous vital bone marrow and dispersed lyophylized allogenic rib cartilage. With postsurgical cavities filled with this transplant, the regeneration of osteal tissue was clearly accelerated in the defect site. This reduced both the rehabilitation terms and complication incidence and improved the cosmetic effect in patients with extensive residual osteal cavities formed during pathological tissues extirpation.

[Effect of titanium on the osteogenic and proliferative potentials of bone marrow cells in vitro].

The impact of titanium (BT-1.0) on proliferative and osteogenic potential of in vitro bone marrow was studied in rabbits. Titanium showed no influence on proliferation and differentiation of osteogenic determined cells precursors in the bone marrow.