Dose-dependent effects of perfluorocarbon-based blood substitute on cardiac function in myocardial ischemia-reperfusion injury.

The main goal of this study was to investigate the cardioprotective properties in terms of effects on cardiodynamics of perfluorocarbon emulsion (PFE) in ex vivo-induced ischemia-reperfusion injury of an isolated rat heart. The first part of the study aimed to determine the dose of 10% perfluoroemulsion (PFE) that would show the best cardioprotective effect in rats on ex vivo-induced ischemia-reperfusion injury of an isolated rat heart. Depending on whether the animals received saline or PFE, the animals were divided into a control or experimental group.

Acute Skin Wounds Treated with Mesenchymal Stem Cells and Biopolymer Compositions Alone and in Combination: Evaluation of Agent Efficacy and Analysis of Healing Mechanisms.

We studied the efficacy of using mesenchymal stem cells (MSC) and a polymeric compound (based on chitosan and cellulose with integrated cerium dioxide nanoparticles (PCCD)) in wound healing, and to compare the effects with various invasive and external drugs used for the same purpose. Two wounds were made on the backs of each of 112 Wistar rats, removing the skin. Eight groups were studied: Control_0-intact wounds; Control_ss-0.

[Autoregulative processes and structural principle of functional selective mobilization].

Autoregulative systems are being formed through dynamical changeability of structural components. Initial structural organization determinates possible variants of regulative connections with different probabilities resulting in a more successful formation of one system and retarding in the appearance of another one. It emphasized the domination of structural principle of functional selective mobilization during the creation of physiological, pathological and ambivalent systems (having, accordingly, adaptive, disadaptive and ambivalent significance).

[Self-organization of physiological, pathological and ambivalent functional systems].

Development of P.K. Anokhin's theory of functional systems rejects the idea of adaptation result as a universal system-forming factor.

[The theory of functional systems and clinical medicine].

The clinical significance of Anokhin's theory of functional systems is analyzed. The concept of a useful result as a universal system-forming factor is debatable. This concept limits the application of the theory to only compensatory-adaptive reactions and, what is more, makes the theory contradictory (the primary achievement of a result usually occurs due to the activity of an already formed system, which excludes its system-forming role).