Light-Driven CO Fixation into Epoxides Using an AlO/CoAlO Composite Photocatalyst.

Utilization of carbon dioxide (CO) as a C1 feedstock to synthesize value-added chemicals using a catalyst made from earth-abundant elements and under mild conditions is a sustainable approach toward carbon neutrality but difficult to achieve. Herein, the CoAlO/AlO composite catalyst is developed and used for the light-driven epoxide to value-added cyclic carbonate conversion using CO. CoAlO/AlO composite catalysts (% Co-AlO) are prepared by calcining cobalt-incorporated Al-oxy-hydroxide at 500 °C under an air atmosphere.

Functionalized amino acid-based injectable hydrogels for sustained drug delivery.

Drug delivery vehicles optimize therapeutic outcomes by enhancing drug efficacy, minimizing side effects, and providing controlled release. Injectable hydrogels supersede conventional ones in the field of drug delivery owing to their less invasive administration and improved targeting. However, they face challenges such as low biodegradability and biocompatibility, potentially compromising their effectiveness.

Unlocking the influence of PNPLA3 mutations on lipolysis: Insights into lipid droplet formation and metabolic dynamics in metabolic dysfunction-associated steatotic liver disease.

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) covers a range of liver conditions marked by the buildup of fat, spanning from simple fatty liver to more advanced stages like metabolic dysfunction-associated steatohepatitis and cirrhosis.

Methods: Our in-depth analysis of PNPLA3_WT and mutants (I148M (MT1) and C15S (MT2)) provides insights into their structure-function dynamics in lipid metabolism, especially lipid droplet hydrolysis and ABHD5 binding. Employing molecular docking, binding affinity, MD analysis, dissociation constant, and MM/GBSA analysis, we delineated distinct binding characteristics between wild-type and mutants.

A panel data study on the role of clean energy in promoting life expectancy.

Purpose: Energy is a health issue. Energy intersects with health outcomes, as evidenced by the relationship between access to clean fuels and technologies and population health measured by life expectancy at birth.

Methods: Utilizing a comprehensive dataset spanning 190 countries from 2000 to 2022, this paper employs a range of static and dynamic panel data models to analyze this empirical relationship, while effectively managing unobserved country-specific heterogeneity and endogeneity issues.