Publications by authors named "A B Perkin"
Article Synopsis
- Multiple Myeloma (MM) is an incurable cancer affecting plasma cells, with over 35,000 new cases diagnosed each year in the U.S., leading to frequent relapses and limited treatment options.
- Researchers used transcriptome sequencing to compare newly diagnosed MM patients with short progression-free survival (PFS) to those with longer PFS, identifying 157 lncRNAs associated with poor outcomes, particularly focusing on one specific lncRNA.
- The study found that the overexpression of this lncRNA enhances cell viability and decreases apoptosis, while its knockdown has the opposite effect, and targeted therapies using antisense oligonucleotides showed potential in reducing cell viability and promoting apoptosis in MM cells.
Multiple Myeloma (MM) is a highly prevalent and incurable form of cancer that arises from malignant plasma cells, with over 35,000 new cases diagnosed annually in the United States. While there are a growing number of approved therapies, MM remains incurable and nearly all patients will relapse and exhaust all available treatment options. Mechanisms for disease progression are unclear and in particular, little is known regarding the role of long non-coding RNAs (lncRNA) in mediating disease progression and response to treatment.
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- The study investigates the mammalian microbiome's role in understanding host-microbial diversity and its impact on health, particularly focusing on nonhuman primates (NHPs).
- It compares microbiome compositions from eight body sites across 17 NHP species, finding that oral microbiomes are distinct and consistent across species, while other body site microbiomes vary by host species.
- The research emphasizes the need for broader studies on microbial diversity to better understand host-microbial relationships and their evolutionary implications, addressing gaps in knowledge beyond just the gut microbiome.
Cryptic diversity and species boundaries within the Paragalago zanzibaricus species complex.
Mol Phylogenet Evol
September 2020
The recently described genus Paragalago is a complex of several nocturnal and morphologically cryptic species distributed in the forests of eastern Africa. Species diversity within this genus has been mainly described using species-specific differences in their loud calls. However, molecular data are still lacking for this group and species boundaries remain unclear.
View Article and Find Full Text PDFDescribing primate biodiversity is one of the main goals in primatology. Species are the fundamental unit of study in phylogeny, behaviour, ecology and conservation. Identifying species boundaries is particularly challenging for nocturnal taxa where only subtle morphological variation is present.
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