Publications by authors named "A B Peck"
The addition of enoxysilanes to vinyl diazonium ions occurs with varying levels of diastereoselectivity. To understand the origins of the stereoselectivity, we studied these transformations using density functional theory (DFT) calculations. The selectivity stems from a stabilizing cation-π interaction that orients the nucleophile and the diazonium ion.
View Article and Find Full Text PDFInterleukin-6 (IL-6)-class inflammatory cytokines signal through the Janus tyrosine kinase (JAK)/signal transducer and activator of transcription (STAT) pathway and promote the development of pancreatic ductal adenocarcinoma (PDAC); however, the functions of specific intracellular signaling mediators in this process are less well defined. Using a ligand-controlled and pancreas-specific knockout in adult mice, we demonstrate in this study that JAK1 deficiency prevents the formation of KRAS-induced pancreatic tumors, and we establish that JAK1 is essential for the constitutive activation of STAT3, whose activation is a prominent characteristic of PDAC. We identify CCAAT/enhancer binding protein δ (C/EBPδ) as a biologically relevant downstream target of JAK1 signaling, which is upregulated in human PDAC.
View Article and Find Full Text PDFObjective: We performed a scoping review of the relevant literature on home-based telehealth in rheumatology to understand its appropriate application in rheumatology practice.
Methods: We searched the Cochrane Library, PubMed, Web of Science, and scientific meeting abstracts to identify articles that specifically addressed telehealth suitability, barriers to telehealth, patient-reported outcomes (PROs) collected in telehealth settings, and telehealth satisfaction. From the initial search of 4,882 studies, 23 reports were included.
Article Synopsis
- The study explored how an organized colorectal cancer screening program using mailed fecal immunochemical tests (FIT) could improve outreach and effectiveness in a large academic-community setting.
- The program was designed with input from leadership, incorporating a structured approach that identified target populations, implementation teams, and quality assurance measures while ensuring patients received proper follow-up care.
- In its first year, the program successfully identified nearly 10,000 eligible patients, achieving a 32% screening completion rate via tests or colonoscopy, suggesting that organized programs can enhance cancer detection efforts.
Profibrotic VEGFR3-Dependent Lymphatic Vessel Growth in Autoimmune Valvular Carditis.
Arterioscler Thromb Vasc Biol
April 2024
Background: Rheumatic heart disease is the major cause of valvular heart disease in developing nations. Endothelial cells (ECs) are considered crucial contributors to rheumatic heart disease, but greater insight into their roles in disease progression is needed.
Methods: We used a -driven EC lineage-tracing approach to identify and track ECs in the K/B.