Publications by authors named "A B Okesina"
Introduction: Human immunodeficiency virus HIV causes a well-known global disease, acquired immunodeficiency syndrome (AIDS), which has a high disease burden in Africa. HIV infection is known to be associated with oxidative stress, which may contribute to disease severity. However, the effect of HAART is equivocal, and requires more studies.
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- - The study investigates how thymoquinone can protect the brain from damage caused by the insecticide cypermethrin, focusing on its effects within the dentate gyrus region responsible for memory and motor functions.
- - Forty adult male rats were divided into five groups, receiving various treatments over 14 days, including combinations of cypermethrin and thymoquinone, followed by tests to assess memory and brain health.
- - Results indicate that thymoquinone improves memory performance and supports brain cell integrity while reducing neurotoxic effects of cypermethrin, suggesting its potential as a treatment for pesticide-related neurotoxicity.
Background: Hypertension remains a major global health challenge, including in low- and middle-income countries. In Rwanda, a lack of adequate information and healthcare services impacts healthcare-seeking behaviors, contributing to undiagnosed hypertension in rural areas. Therefore, the need to determine its prevalence and associated factors.
View Article and Find Full Text PDFType 2 diabetes mellitus (T2DM), characterized by insulin resistance and glucose dysmetabolism, is a major metabolic disorder accompanied with health and financial burden. Recently, research findings showed that orange peel extract (OPE) has health benefits such as improved insulin sensitivity and glucose metabolism. The present study aimed at establishing the role of naringin from OPE on T2DM-induced glucose and lipid dysmetabolism.
View Article and Find Full Text PDFNaringin from sweet orange peel improves testicular function in high fat diet-induced diabetic rats by modulating xanthine oxidase/uric acid signaling and maintaining redox balance.
Lab Anim Res
February 2024
Article Synopsis
- Type 2 diabetes mellitus (T2DM) can negatively impact testicular function, and this study aimed to examine the effects of naringin, a compound from orange peel, on T2DM-related testicular dysfunction in male Wistar rats.
- The results showed that naringin reduced high blood sugar levels and improved sperm quality, hormones, and antioxidant capacity, while also decreasing markers of oxidative stress and inflammation.
- The findings suggest that naringin could be a beneficial supplement for addressing male infertility caused by T2DM, even though oral orange peel extract had a more pronounced effect.