Serodiagnosis of urogenital schistosomiasis and profiling of immunoreactive protein(s) in Schistosoma haematobium soluble egg and adult worm antigens.

Background Objectives: To achieve schistosomiasis eradication plan by 2030, the development of efficient diagnosis is crucial. This study focuses on assessing the immunodiagnostic potential of S. haematobium (Sh) soluble egg antigen (SEA) and worm antigen (SWA) for urogenital schistosomiasis.

Endemic status of urogenital schistosomiasis and the efficacy of a single-dose praziquantel treatment in unmapped rural farming communities in Oyo East Local Government Area, Oyo State, Nigeria.

Background: Schistosomiasis is endemic in Nigeria, and the treatment is largely concentrated on children enrolled in schools. Consequently, the coverage of non-enrolled school-aged children is often neglected. Ajagba and Awosan are two communities in Nigeria that have never had any control intervention.

Isolation and In Vitro and In Vivo Activity of Secondary Metabolites from Baker against Malaria Parasites.

Chemical investigation of the antimalarial medicinal plant led to the isolation of five new diterpenoids, including ajugarins VII-X (-) and teuvincenone K (), along with four known compounds, namely, 12,16-epoxy-6,11,14,17-tetrahydroxy-17(15 → 16)--5,8,11,13,15-abietapentaen-7-one (), methyl pheophorbide A (), loliolide (), and acacetin (). The chemical structures of the new compounds were elucidated using NMR spectroscopy, mass spectrometry, circular dichroism, as well as density functional theory calculations. All compounds were evaluated for activity against 3D7 malaria parasites with methyl pheophorbide A () showing the strongest activity (IC 4.

Temporal modelling of Lymnaea natalensis (Krauss, 1848) in tropical aquatic habitats.

Lymnaea natalensis is the only snail intermediate host of Fasciola gigantica, the causative agent of fascioliasis, in Nigeria. The species also serves as intermediate host for many other African trematode species of medical and veterinary importance, and it is found throughout the country. However, there is no detailed information on the factors that influence its distribution and seasonal abundance in the tropical aquatic habitats in Nigeria.

Models for predicting bulinids species habitats in southwestern Nigeria.

Background: Schistosomiasis prevalence is high in southwestern Nigeria and planorbids of the genus had been implicated in the transmission of the disease in the area. The knowledge of species distribution in relation to environmental variables will be auspicious in planning control strategies.

Methods: Satellite imagery and geographic information system (GIS) were used to develop models for predicting the habitats suitable for bulinid species.