Publications by authors named "A B Newland"
Human nails have recently become a sample of interest for toxicological purposes. Multiple studies have proven the ability to detect various analytes within the keratin matrix of the nail. The analyte of interest in this study is fentanyl, a highly dangerous and abused drug in recent decades.
View Article and Find Full Text PDFThe prominence of fentanyl and fentanyl analogues or Fentanyl Related Substances (FRS) has driven a nationwide crisis of opioid overdoses, which significantly presents an issue for public health and safety. Originally developed for medical purposes, fentanyl and FRS have become critical contributors to opioid overdose deaths due to their distribution, availability, and potency. This study examined toxicodynamic properties between butyrylcholinesterase (BChE) and fentanyl analogues via Ellman's assay.
View Article and Find Full Text PDFArticle Synopsis
- Immune thrombocytopenia (ITP) is an autoimmune disorder that leads to low platelet counts, increased bleeding risk, and is characterized by the body's immune system attacking its own platelets and their precursors.
- Treatments for ITP, such as corticosteroids and thrombopoietin receptor agonists (TPO-RAs) like Romiplostim, focus on boosting platelet production and preventing hemorrhage.
- This review will cover the complex workings of ITP and explore how Romiplostim not only increases platelet production but may also have effects on immune regulation.
Toolmark and Firearm examiners' opinions have fallen under scrutiny as inadmissible ballistics evidence has led to the possibility of wrongful convictions and cold cases that could have been solved with the presence of a physical bullet, casing, and/or weapon at the crime scene. This research provides a solution for subjective-based conclusions and the absence of physical evidence altogether. Analysis of bullet material using Atomic Absorption Spectroscopy (AAS) has distinguished bullet composition between manufacturers from a surface scratch.
View Article and Find Full Text PDFObjective: Identify patient experience and preference towards thrombopoietin-receptor agonists (TPO-RAs) in treatment of immune thrombocytopenia (ITP) in the Netherlands.
Methods: The Thrombopoietin-Receptor Agonist Patient experience (TRAPeze) survey used a discrete choice experiment (DCE) to elicit patient preferences and a patient burden survey (PBS) to evaluate the clinical and social impact of ITP. TRAPeze collected responses from 6th October to 19th November 2021.