Publications by authors named "A B Nazarov"
20-Hydroxyecdysone (20E) is an arthropod steroid hormone that possesses a number of beneficial pharmacological activities in humans, including anabolic, antioxidant, hypoglycemic, cardioprotective, hepatoprotective, neuroprotective, and antineoplastic properties, etc. While several studies have explored the anabolic activity of 20E in muscle cells, they have concentrated on its effects on myofibril size, protein biosynthesis intensity, and myostatin expression, without assessing energy metabolism. In this research, we have demonstrated that 20E boosts both catabolism and anabolism, coupling energy-producing and biosynthetic metabolic processes in mouse myoblasts and fibroblasts in the same way.
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- Systematic reviews (SRs) use standardized methods to evaluate evidence for specific research questions, but they often require significant time and human resources, particularly for larger studies.
- Researchers are exploring the use of artificial intelligence (AI) to streamline the screening process for articles, aiming to maintain the integrity of the review while reducing workload.
- A study evaluated the AI tool Sciome SWIFT-ActiveScreener, which showed over 95% agreement with human screeners on article selection and was found to be user-friendly for both novice and experienced researchers.
[Melanoma metastasis to the brachial plexus and median nerve. A rare clinical case].
Zh Vopr Neirokhir Im N N Burdenko
October 2024
Article Synopsis
- * In some cases, doctors may find that melanoma has spread before identifying the original tumor, which can make diagnosis challenging.
- * The report highlights a specific patient case involving metastasis of melanoma to the left median nerve and brachial plexus, leading to surgical intervention for treating the metastasis and addressing median neuropathy.
Article Synopsis
- The study focuses on creating new cancer-fighting agents by combining ruthenium complexes with the drug abiraterone acetate to utilize the strengths of both.
- The resulting compounds show strong anti-cancer effects on cancer cells while sparing normal fibroblast cells, indicating selectivity.
- One specific compound, dichlorido(η6-p-cymene)(abiraterone acetate)ruthenium(II), demonstrated significantly better anti-cancer activity and induced apoptosis more effectively than abiraterone alone, suggesting it could be a promising candidate for further research.
The prevalence of treatment-resistant depression within global and military populations highlights the need for novel treatment approaches beyond monoamine neurotransmitter modulators. Buprenorphine (BUP), a semi-synthetic partial opioid agonist, is approved for the treatment of opioid use disorder and has shown promise in treating both depression and chronic pain. This case report discusses the use of transdermal BUP in treating a 36 year-old man with treatment-resistant depression with prominent anhedonia, military-related posttraumatic stress disorder, and chronic pain because of barosinusitis.
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