Publications by authors named "A B Miroshnikov"
Tactile and motor imagery are crucial components of sensorimotor functioning and cognitive neuroscience research, yet the neural mechanisms of tactile imagery remain underexplored compared to motor imagery. This study employs multichannel functional near-infrared spectroscopy (fNIRS) combined with image reconstruction techniques to investigate the neural hemodynamics associated with tactile (TI) and motor imagery (MI). In a study of 15 healthy participants, we found that MI elicited significantly greater hemodynamic responses (HRs) in the precentral area compared to TI, suggesting the involvement of different cortical areas involved in two different types of sensorimotor mental imagery.
View Article and Find Full Text PDFError-related potentials (ErrPs) have attracted attention in part because of their practical potential for building brain-computer interface (BCI) paradigms. BCIs, facilitating direct communication between the brain and machines, hold great promise for brain-AI interaction. Therefore, a comprehensive understanding of ErrPs is crucial to ensure reliable BCI outcomes.
View Article and Find Full Text PDFEnzymatic Transglycosylation Features in Synthesis of 8-Aza-7-Deazapurine Fleximer Nucleosides by Recombinant PNP: Synthesis and Structure Determination of Minor Products.
Biomolecules
July 2024
Article Synopsis
- Enzymatic transglycosylation of a specific fleximer base using recombinant purine nucleoside phosphorylase (PNP) resulted in the production of both expected and unexpected reaction products, including N1-pyrazole nucleosides and novel derivatives.
- The study revealed that certain minor products, like a 4-imino-pyridinium riboside and bis-ribose derivatives, were formed, while a particular expected product (4-imino-pyridinium deoxyriboside) was absent.
- Molecular modeling helped identify how the structure of the heterocyclic substrates interacts with the PNP active site, suggesting that the spatial arrangement may facilitate secondary glycosylation, leading to
1,2,4-Triazole derivatives have a wide range of biological activities. The most well-known drug that contains 1,2,4-triazole as part of its structure is the nucleoside analogue ribavirin, an antiviral drug. Finding new nucleosides based on 1,2,4-triazole is a topical task.
View Article and Find Full Text PDFBody composition assessment is often used in clinical practice to assess and monitor nutritional status. For example, body fat mass is a predictor of metabolic diseases, and for an athlete it is a criterion of performance. "Gold standard" - the method of dual-energy X-ray absorptiometry - in contrast to bioelectrical impedance analysis, is difficult to apply in everyday clinical practice.
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