At the nucleus of cancer: how the nuclear envelope controls tumor progression.

Historically considered downstream effects of tumorigenesis-arising from changes in DNA content or chromatin organization-nuclear alterations have long been seen as mere prognostic markers within a genome-centric model of cancer. However, recent findings have placed the nuclear envelope (NE) at the forefront of tumor progression, highlighting its active role in mediating cellular responses to mechanical forces. Despite significant progress, the precise interplay between NE components and cancer progression remains under debate.

TP53 gene status can promote sensitivity and resistance to chemotherapeutic drugs and small molecule signal transduction inhibitors.

TP53 is normally a tumor suppressor. However, it is mutated in at least 50% of human cancers. Usually, we assume that mutation of the TP53 is associated with loss of sensitivity to various drugs as in most cases wild type (WT) TP53 activity is lost.

An Enhanced Bioactive Glass Composition with Improved Thermal Stability and Sinterability.

The development of new bioactive glasses (BGs) with enhanced bioactivity and improved resistance to crystallization is crucial for overcoming the main challenges faced by commercial BGs. Most shaping processes require thermal treatments, which can induce partial crystallization, negatively impacting the biological and mechanical properties of the final product. In this study, we present a novel bioactive glass composition, S53P4_MSK, produced by a melt-quench route.

Are we ready for the application of the EU Regulation on wastewater reuse in agriculture? A techno-economic preliminary evaluation based on a case-study.

Reuse of reclaimed wastewater (RWW) in agriculture represents one of the key strategies to promote for reducing the pressures on water sources, as also fostered by the EU governance. Indeed, the European Regulation 741/2020 on water reuse, entered into force in 2023, was issued with the aim to extend the reuse of treated water in agriculture under safe conditions. It establishes the minimum quality requirements; it also foresees the possibility to add additional requirements, especially for contaminants of emerging concern (CECs), based on "scientific evidence" and the risk assessment.

Design, synthesis and biological evaluation of new H2S-releasing rivastigmine derivatives as neuroprotective molecules.

Alzheimer's disease (AD) represents one of the main challenges for the 21st century medical research as no disease-modifying agent has been successfully progressed to the market, while the number of people affected by AD is estimated to grow exponentially over the next years. The complex network of triggering factors involved in the insurgence and progression of AD can be rightly addressed as one of the main reasons behind the difficulty in identifying new pharmacological approaches. For this reason, the discovery and development of drugs endowed with pleiotropic activity remain the most valuable, but at the same time challenging, approaches to tackle down AD.