Publications by authors named "A B M Rabiul Alam Beg"
Article Synopsis
- A reliable RP-HPLC method with UV detection was developed for the accurate measurement of Voriconazole in pure and gel formulations, using a 50:50 acetonitrile-water mobile phase and a flow rate of 1.0 ml/min.
- The method demonstrated excellent linearity (correlation coefficient = 0.9999) and precision, with a percentage relative standard deviation (RSD) of less than 2.0.
- Robustness was evaluated using variables like flow rate and pH; while flow rate significantly affected drug concentration, the method remained straightforward and suitable for daily quality control with a retention time of under 4 minutes.
Necroptosis can promote antigen-specific immune responses, suggesting induced necroptosis as a therapeutic approach for cancer. Here we sought to determine the mechanism of immune activation but found the necroptosis mediators RIPK3 and MLKL dispensable for tumor growth in genetic and implantable models of breast or lung cancer. Surprisingly, inducing necroptosis within established breast tumors generates a myeloid suppressive microenvironment that inhibits T cell function, promotes tumor growth, and reduces survival.
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- This study investigates gene expression differences in Small Cell Lung Cancer (SCLC) to find potential biomarkers that could enhance clinical testing and treatment options.
- Researchers used RNA expression profiling on tumor samples from SCLC patients and found a strong correlation between their methods and traditional sequencing techniques, revealing varying gene expressions between primary and metastatic sites.
- The findings suggest that profiling SCLC at a clinical level can aid in identifying specific subtypes, which could be crucial for designing more effective clinical trials and targeted therapies for patients.
Commensal bacteria that breach endothelial barrier has been reported to induce low grade chronic inflammation producing disease symptoms in major peripheral tissues. In this study, we investigated the role of genetically modified cellular invasive form of commensal E. coli K12 (SK3842) in cognitive impairment.
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- Pure intertubular seminoma (PITS) is a rare type of testicular cancer where seminoma cells are found in testicular interstitium without forming a noticeable mass or diffuse growth, leading to challenges in diagnosis.
- This condition often goes unnoticed and is usually diagnosed incidentally during evaluations for testicular pain, infertility, or other issues, with only a minority of cases presenting with metastasis.
- A study involving 15 patients revealed that the average age at presentation was 29, and common symptoms included undescended testis, testicular pain, and infertility, while most patients had normal serum markers and no visible tumors at the time of diagnosis.