Discovering potential ERK1 inhibitors from natural products for therapeutic targeting of Alzheimer's disease.

Background: Extracellular signal-regulated kinase 1 (ERK1) belongs to mitogen-activated protein kinases, which are essential for memory formation, cognitive function, and synaptic plasticity. During Alzheimer's disease (AD), ERK1 phosphorylates tau at 15 phosphorylation sites, leading to the formation of neurofibrillary tangles. The overactivation of ERK1 in microglia promotes the release of pro-inflammatory cytokines, which results in neuroinflammation.

Red and NIR light-triggered enhancement of anticancer and antibacterial activities of dinuclear Co(II)-catecholate complexes.

Photoactive complexes of bioessential 3d metals, activable within the phototherapeutic window (650-900 nm), have gained widespread interest due to their therapeutic potential. Herein, we report the synthesis, characterization, and light-enhanced anticancer and antibacterial properties of four new dinuclear Co(II) complexes: [Co(phen)(cat)] (Co-1), [Co(dppz)(cat)] (Co-2), [Co(phen)(esc)] (Co-3), and [Co(dppz)(esc)] (Co-4). In these complexes, phen (1,10-phenanthroline) and dppz (dipyrido[3,2-:2',3'-]phenazine) act as neutral N,N-donor ligands, while cat and esc serve as O,O-donor catecholate ligands derived from catechol (1,2-dihydroxybenzene) and esculetin (6,7-dihydroxy coumarin).

Identification of differentially expressed non-coding RNAs in the plasma of women with preterm birth.

This study aimed to identify differentially expressed non-coding RNAs (ncRNAs) associated with preterm birth (PTB) and determine biological pathways being influenced in the context of PTB. We processed cell-free RNA sequencing data and identified seventeen differentially expressed (DE) ncRNAs that could be involved in the onset of PTB. Per the validation via customized RT-qPCR, the recorded variations in expressions of eleven ncRNAs were concordant with the analyses.

Electrochemical Detection of Hydrogen Peroxide at High Concentrations Using Hastelloy G35 Electrode.

The detection of hydrogen peroxide (HO) at elevated concentrations while eliminating oxygen interference presents a significant challenge. Nickel-based stainless steel, such as Hastelloy G35, has shown excellent corrosion resistance. However, it has never been used in electroanalysis.

Energy-Efficient and Trust-Based Autonomous Underwater Vehicle Scheme for 6G-Enabled Internet of Underwater Things.

This paper introduces a novel energy-efficient lightweight, void hole avoidance, localization, and trust-based scheme, termed as Energy-Efficient and Trust-based Autonomous Underwater Vehicle (EETAUV) protocol designed for 6G-enabled underwater acoustic sensor networks (UASNs). The proposed scheme addresses key challenges in UASNs, such as energy consumption, network stability, and data security. It integrates a trust management framework that enhances communication security through node identification and verification mechanisms utilizing normal and phantom nodes.