Publications by authors named "A B Laursen"
Study Question: To what extent is male physical activity (PA) associated with fecundability (per-cycle probability of conception)?
Summary Answer: Preconception levels of vigorous, moderate, or total PA were not consistently associated with fecundability across Danish and North American cohorts, but there was suggestive evidence that bicycling with a 'soft, comfort seat' was associated with reduced fecundability in both cohorts, especially among males with greater BMI.
What Is Known Already: Among males, some studies indicate that moderate PA might improve fertility, whereas vigorous PA, especially bicycling, might be detrimental.
Study Design, Size, Duration: We assessed the association between male PA and fecundability among couples participating in two preconception cohort studies: SnartForaeldre.
Article Synopsis
- Anifrolumab is a monoclonal antibody used to treat systemic lupus erythematosus (SLE) but comes with a heightened risk of viral infections, notably herpes zoster (HZ), with reported rates of 6.1% in clinical trials.
- In two unique cases, SLE patients on anifrolumab experienced severe herpesvirus infections—disseminated HSV-2 and HZ encephalitis—marking a concerning new trend not previously documented.
- The findings underline the importance of assessing patients' viral infection history and recommending vaccinations, like the recombinant zoster vaccine, before starting anifrolumab therapy to mitigate infection risks.
Background: The use of fertility indicators to predict ovulation has largely been studied for contraceptive purposes, while less so as fertility-promoting tools.
Objective: To investigate the association between fertility indicators and fecundability in Danish women trying to conceive.
Methods: Web-based preconception cohort study.
This study investigates the presence of antinuclear antibodies (ANA) in three primary synucleinopathies - Parkinson's disease (PD), multiple system atrophy (MSA), and dementia with Lewy bodies (DLB), compared to healthy controls. Autoinflammatory disorders typically involve the immune system mistakenly attacking the body's own cells and start producing ANA. There is an increasing body of evidence that immune-mediated inflammation is a pathological feature linked to synucleinopathies.
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