Publications by authors named "A B Kunnumakkara"
The increasing prevalence of chronic diseases and their associated morbidities demands a deeper understanding of underlying mechanism and causative factors, with the hope of developing novel therapeutic strategies. Autophagy, a conserved biological process, involves the degradation of damaged organelles or protein aggregates to maintain cellular homeostasis. Disruption of this crucial process leads to increased genomic instability, accumulation of reactive oxygen species (ROS), decreased mitochondrial functions, and suppression of ubiquitination, leading to overall decline in quality of intracellular components.
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- - The prognosis for triple-negative breast cancer (TNBC) is challenging due to its heterogeneity and a lack of effective targeted therapies, prompting research into tyrosine kinases (TKs) as crucial contributors to tumor behavior and potential treatment targets.
- - Recent advancements in precision medicine have led to the exploration of various TK-targeted therapies, including monoclonal antibodies and small molecule inhibitors, that aim to combat TNBC by targeting key proteins like EGFR and VEGF.
- - The review emphasizes the importance of molecular characterization of TNBCs to maximize the effectiveness of TK-targeted therapies, indicating that treatment outcomes can significantly vary based on patient diversity.
Article Synopsis
- - Bile acid transporters (BATs) are important proteins that help move bile acids in the body, especially in the liver, kidney, and small intestine, and are linked to fat absorption and liver function.
- - Altered levels of bile acids are associated with cancer, but the specific role of BATs in cancer progression—like tumor growth and spread—has not been fully explored yet.
- - This review suggests that researching BATs further could lead to new cancer treatments, especially for liver and gastrointestinal cancers, and encourages targeting these transporters with different techniques for potential therapies.
Nuclear receptors (NRs) function as crucial transcription factors in orchestrating essential functions within the realms of development, host defense, and homeostasis of body. NRs have garnered increased attention due to their potential as therapeutic targets, with drugs directed at NRs demonstrating significant efficacy in impeding chronic disease progression. Consequently, these pharmacological agents hold promise for the treatment and management of various diseases.
View Article and Find Full Text PDFDespite significant advancements in chemotherapy, effective treatments for advanced cancer stages remain largely elusive due to chemoresistance. Resistance to anticancer agents in cancer cells can arise through various mechanisms, including multi-drug resistance, inhibition of apoptosis, modification of drug targets, and enhancement of DNA repair capabilities. Consequently, there is a critical need for agents that can suppress the molecular signatures responsible for drug resistance.
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