[Dihydroquercetin as a systemic neuroprotector for the prevention and treatment of β-amyloid-associated brain diseases].

Dihydroquercetin (DHQ) is a plant-derived polyphenol belonging to the group of flavonoids. In models associated with abnormal accumulation of -amyloid in the brain (Alzheimer's disease and cerebral amyloid angiopathy), DHQ demonstrates the ability to disaggregate toxic forms of -amyloid and prevent their formation. It is believed that this phenomenon underlies the protective effect of DHQ on brain neurons.

[Anthocyanins for the prevention and treatment of neurodegenerative diseases].

Anthocyanins are water-soluble polyphenolic pigments widely present in fruits and vegetables. These compounds have extensive biological activity and are able to penetrate the brain and modulate its functions. In neurodegenerative processes, anthocyanins contribute to the survival of neurons.

[Gut microbiome as a therapeutic target in the treatment of depression and anxiety].

There is a bi-directional connection between the gut microbiome and the brain. Changes in the composition of the microbiome affect emotions, behavior, and the stress response involved in the pathogenesis of depression. Depression and anxiety are often associated with dysbiosis and inflammatory bowel disease.

[Curcumin as an ajuvant treatment of depression: mechanisms of action and application prospects].

Curcumin, a natural compound found in the rhizomes of turmeric, has a pronounced anti-inflammatory activity. Rodent models of depression show that this activity is similar to the effect of antidepressants (AD). Experimental data indicate that this activity may be related to the effect of curcumin on the monoamine cycle, oxidative and nitrosative stress, neurogenesis, hypothalamic-pituitary-adrenal, and immune systems.

[Neurobiological effects of theanine and its possible use in neurology and psychiatry].

Theanine is an analog of glutamate and the major aminoacid in green tea. It has received growing attention in recent years because of its beneficial effects on the central nervous system. Theanine was shown to increase levels of brain-derived neurotrophic factor and to stimulate neurogenesis.