Trypanosome doublet microtubule structures reveal flagellum assembly and motility mechanisms.

The flagellum of drives the parasite's characteristic screw-like motion and is essential for its replication, transmission, and pathogenesis. However, the molecular details of this process remain unclear. Here, we present high-resolution (up to 2.

Simvastatin loaded surface-decorated 3D-dendritic mesoporous silica nanoparticles for enhanced antihyperlipidemic activity: in vitro and in vivo appraisal.

Simvastatin is a potent statin with antioxidant and anti-inflammatory characteristics, often used to treat hyperlipidemia and related cardiovascular disorders. Nonetheless, its therapeutic advantages are limited by poor water solubility and substantial degradation by CYP3A4 enzymes. This research aimed to improve simvastatin's physicochemical characteristics and therapeutic effectiveness by developing 3D-dendritic mesoporous silica nanoparticles as nanocarriers.

Assessment of contraceptive use and side effects among women in five countries across the Middle East: a cross-sectional study.

Purpose: Contraceptive use and associated adverse effects are underreported in the Middle East. This study aimed to investigate contraceptive use and reported side effects in five Middle Eastern countries.

Methods: This study, conducted over eight weeks in the UAE, Egypt, Jordan, Syria, and Iraq, utilized an online closed-ended structured questionnaire to extract the study information.

Organelle-Specific Thiochromenocarbazole Imide Derivative as a Heavy-Atom-Free Type I Photosensitizer for Biomolecule-Triggered Image-Guided Photodynamic Therapy.

Modern photodynamic therapy (PDT) demands next-generation photosensitizers (PSs) that overcome heavy-atom dependency and enhance efficacy beyond traditional, highly oxygen-dependent type II mechanisms. We introduce herein , as a thiochromenocarbazole imide derivative designed for type I photodynamic action. Upon light activation, efficiently favors superoxide (O) and PS-centered radical formation instead of singlet oxygen (O) generation.

Larvicidal Effects of Cymbopogon commutatus Essential Oil and Its Based Nanoformulations on Culex pipiens: Chemical Profiling and Physicochemical Characterization.

Cymbopogon commutatus has been used as an ingredient in the manufacturing of soap and mosquito repellent. Herein, the chemical profiling of the C. commutatus aerial parts essential oil (CCEO) was constructed on the basis of the multiplex of GC-MS and nuclear magnetic resonance (NMR).