Publications by authors named "A B Jonsdottir"
Hypercalcemia in monoclonal gammopathy of undetermined significance (MGUS) presents a clinical challenge since it may indicate progression to multiple myeloma (MM) but could also be due to a multitude of unrelated disorders. To inform the approach to this clinical challenge, we conducted a nested cohort study within the iStopMM screening study. Of the 75,422 Icelanders aged 40 years and above who underwent screening for MGUS, we included 2,546 with MGUS who were in active follow-up, including regular serum calcium measurements.
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- The study aims to investigate the genetic factors associated with accessory atrioventricular pathways (APs) and related heart rhythm disorders using a genome-wide association study (GWAS).
- It involved analyzing genetic data from over 1,200,000 control individuals and 2,310 individuals with APs from multiple countries and various health databases.
- Key findings revealed three significant genetic variants linked to APs, particularly in specific genes (CCDC141 and SCN10A), with implications for understanding conditions like paroxysmal supraventricular tachycardia (PSVT).
Importance: Recurrent pericarditis is a treatment challenge and often a debilitating condition. Drugs inhibiting interleukin 1 cytokines are a promising new treatment option, but their use is based on scarce biological evidence and clinical trials of modest sizes, and the contributions of innate and adaptive immune processes to the pathophysiology are incompletely understood.
Objective: To use human genomics, transcriptomics, and proteomics to shed light on the pathogenesis of pericarditis.
The goal of this study was to guide the early conceptual designs of two devices intended to improve the quality of life for patients on hemodialysis: a portable hemodialysis device and a wearable hemodialysis device. Thirty-two nephrology nurses were interviewed using a mixed approach of open-ended, rating, and rank-order questions. Results show most nurses try to persuade patients to try a modality of treatment that offers them the best clinical outcome and highest quality of life.
View Article and Find Full Text PDFMost of the Earth's surface has now been modified by humans. In many countries, natural and semi-natural ecosystems mostly occur as islands, isolated by land converted for agriculture and a variety of other land-uses. In this fragmented state, long-distance dispersal may be the only option for species to adapt their ranges in response to changing climate.
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