Publications by authors named "A B Huisman"
Background: Efanesoctocog is a B-domain-deleted, Fc-fusion FVIII linked to the D'D3 domain of VWF and two XTEN polypeptides, designed for an ultra-extended half-life for prophylaxis in hemophilia A, but also aiding in managing acute bleeding or surgery in patients on long-term emicizumab. However, no current laboratory method accurately measures FVIII levels in the presence of emicizumab. We hypothesized that the chromogenic (CSA) FVIII assay, specifically calibrated for efanesoctocog using bovine coagulation factors, could provide an accurate assessment of efanesoctocog activity.
View Article and Find Full Text PDFBackground: Genetic selection improves a population by increasing the frequency of favorable alleles. Understanding and monitoring allele frequency changes is, therefore, important to obtain more insight into the long-term effects of selection. This study aimed to investigate changes in allele frequencies and in results of genome-wide association studies (GWAS), and how those two are related to each other.
View Article and Find Full Text PDFArticle Synopsis
- - Kisspeptin plays a crucial role in regulating gonadotropin secretion in pigs, and a study was conducted on F1 pigs from a parental line created by CRISPR/Cas9 knockout of the KISS1 gene, which eliminates the need for castration.
- - The research measured body weights, gonadotropin levels, and reproductive development in these pigs, finding that while body weight didn't differ based on genotype, KISS1-/- boars and gilts exhibited significantly reduced gonadotropin concentrations and experienced hypogonadism.
- - The results suggest that only one functional KISS1 allele is necessary for normal gonadal function and hormone secretion, and that the knockout of KISS1 does