Publications by authors named "A B Hreidarsson"
Autoimmune thyroid disease is the most common autoimmune disease and is highly heritable. Here, by using a genome-wide association study of 30,234 cases and 725,172 controls from Iceland and the UK Biobank, we find 99 sequence variants at 93 loci, of which 84 variants are previously unreported. A low-frequency (1.
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- Lp(a) is a risk factor for cardiovascular diseases, with its molar concentration being more significant than apo(a) size in contributing to this risk.
- A study involving over 143,000 Icelanders found that higher Lp(a) levels are linked to various cardiovascular conditions, while low levels may increase the risk of type 2 diabetes (T2D).
- Reducing Lp(a) levels in individuals with the highest concentrations could potentially lower coronary artery disease (CAD) risk without raising the risk of T2D.
Aims: Type1 diabetes is generally regarded as an abruptly presenting disease in children without family history. The incidence and prevalence of insulin requiring diabetes in adults is unclear. The aim of this study was to clarify this issue by examining the epidemiology of type 1 diabetes diagnosed in adulthood in a countrýs whole population.
View Article and Find Full Text PDFUrine dipstick tests are widely used in routine medical care to diagnose kidney and urinary tract and metabolic diseases. Several environmental factors are known to affect the test results, whereas the effects of genetic diversity are largely unknown. We tested 32.
View Article and Find Full Text PDFSequence variants that affect mean fasting glucose levels do not necessarily affect risk for type 2 diabetes (T2D). We assessed the effects of 36 reported glucose-associated sequence variants on between- and within-subject variance in fasting glucose levels in 69,142 Icelanders. The variant in TCF7L2 that increases fasting glucose levels increases between-subject variance (5.
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