Publications by authors named "A B Hoi"
Objective: High disease activity status (HDAS) in patients with systemic lupus erythematosus (SLE) is associated with adverse long-term outcomes. We examined the frequency of lupus low disease activity state (LLDAS) and remission (REM) attainment in HDAS patients and whether their attainment was associated with improved patient outcomes.
Methods: Demographic, clinical and outcomes data, collected prospectively from a multinational cohort between 2013 and 2020, were analysed.
Article Synopsis
- The lupus low disease activity state (LLDAS) allows some activity in systemic lupus erythematosus (SLE) as long as it stays within certain limits; this study examined the outcomes of patients achieving LLDAS with different levels of activity.
- A total of 2,099 SLE patients were analyzed over a median follow-up of 3.5 years, revealing that 20.8% had clinical activity, 50.4% had serological activity only, and 28.8% had neither while in LLDAS.
- Results indicated that all LLDAS subsets reduced the risk of disease flares and damage, with LLDAS showing no activity being the most protective against severe flares.
Article Synopsis
- Systemic lupus erythematosus (SLE) primarily affects women around their childbearing years, and this study focuses on the risk factors and frequency of adverse pregnancy outcomes (APOs) in an Australian group of female SLE patients.
- The research included a review of pregnancy histories from 278 participants, revealing a 44.3% rate of APOs, most commonly involving prematurity and associated with younger ages at SLE diagnosis and specific antibody presence.
- The findings highlight the importance of pre-pregnancy counseling and collaboration among healthcare specialists for women with SLE, particularly those diagnosed at a younger age, to manage the risks of pregnancy effectively.
Objectives: Anti-Ro60 and anti-Ro52 autoantibodies are frequently used as diagnostic biomarkers for Sjogren's disease, but their clinical significance in systemic lupus erythematosus (SLE) is not well characterised.
Methods: Patients fulfilling SLE classification criteria were studied according to their anti-Ro status. We defined Ro positivity (Ro+) as those who have either anti-Ro60 or anti-Ro52 positivity.