Publications by authors named "A B Heimberger"

Purpose: A glioblastoma (GBM) is a primary brain tumor with significant unmet therapeutic needs. Immune checkpoint inhibitors (ICIs) have marked therapeutic benefits in many different cancers but have yet to show benefit for most GBM patients in phase III trials.

Methods: A systematic review querying ClinicalTrials.

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Article Synopsis
  • The study highlights a shift in immunology focus from adaptive immune cells to the role of myeloid cells in tumors like glioblastoma, which lack T cells and are dominated by immunosuppressive cells.
  • It discusses potential therapeutic strategies targeting myeloid-specific immune checkpoints, alongside some shared targets with adaptive immunity.
  • By reviewing existing research on the effects of various immune checkpoint pathways, the authors aim to identify and prioritize new treatment options for glioblastoma.
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Article Synopsis
  • Patients with brain tumors want to help doctors understand their illness better by participating in tests that involve taking samples of their tumor tissue.
  • To improve treatments, everyone including patients, researchers, and regulatory agencies need to work together and use consistent methods when taking these samples.
  • Even though new tests using blood samples show some promise, they can't replace the need for the usual tissue tests just yet, and it's important to clearly explain the risks and benefits of these procedures to patients.
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Tumor-associated macrophages and microglia (TAMs) are critical for tumor progression and therapy resistance in glioblastoma (GBM), a type of incurable brain cancer. We previously identified lysyl oxidase (LOX) and olfactomedin like-3 (OLFML3) as essential macrophage and microglia chemokines, respectively, in GBM. Here, single-cell transcriptomics and multiplex sequential immunofluorescence followed by functional studies demonstrate that macrophages negatively correlate with microglia in the GBM tumor microenvironment.

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