Publications by authors named "A B Gaye"
Estrogen hormones are primarily associated with their role as female sex hormones responsible for primary and secondary sexual development. Estrogen receptors are known to undergo age-dependent decreases due to age-related changes in hormone production. In the mitochondria, estrogen functions by reducing the production of reactive oxygen species in the electron transport chain, inhibiting apoptosis, and regulating mitochondrial DNA content.
View Article and Find Full Text PDFTumoral dermatophytic pseudomycetoma caused by Microsporum langeronii.
Ann Dermatol Venereol
December 2024
Article Synopsis
- The study investigates the connection between taste perception pathways and Alzheimer's disease, focusing on neurotransmitters and genetic factors that may contribute to neurodegenerative conditions.
- It involves analyzing taste perception genes in a sample of 475 African American individuals, combining data from eQTLs and SNPs identified in previous Alzheimer's GWAS studies.
- The results highlight 3,547 significant SNP-Gene associations, with three specific SNPs consistently linked to Alzheimer's, pointing to the potential role of taste perception in the disease's progression.
Background: Arterial stiffness, commonly assessed via pulse wave velocity (PWV), is marked by reduced arterial elasticity and serves as a significant risk factor for cardiovascular disease and an early indicator of hypertension. This study investigated the regulatory roles of long non-coding RNAs (lncRNAs) in modulating mRNAs associated with arterial stiffness and hypertension, with a particular focus on African Americans, a population disproportionately impacted by hypertension.
Methods: We utilized whole-blood transcriptome sequencing data from two African American (AA) cohorts with high hypertension prevalence: the GENE-FORECAST study (436 subjects) and the MH-GRID study (179 subjects).