Evaluation of intravenous lorazepam dosing strategies and the incidence of refractory status epilepticus.

Introduction: Status epilepticus (SE) is a neurological emergency associated with high mortality if not identified and treated promptly. For the emergent treatment of SE, the recommended intravenous (IV) lorazepam dose is 0.1 mg/kg/dose, up to a maximum of 4 mg.

Forensic science educational programs (VI) - Programs in the US.

Historically, academic forensic science (FS) programs in the US tended to be relatively small and were embedded in a criminal justice, chemistry, or biology department. Then, in the early 2000s, interest in FS surged, many colleges and universities responded to student demand by adding FS degrees to their curriculums. The search for forensic science programs in the US was done online, using the American Academy of Forensic Sciences' Forensic Science Education Program Accreditation Commission (FEPAC) list of accredited programs, the CollegeSource® Online Google search, Universities.

Enhanced pirmenol elimination by rifampin.

The potential for drug-drug interaction between pirmenol, an extensively metabolized antiarrhythmic agent, and rifampin, a potent inducer of hepatic drug-metabolizing enzymes, was evaluated in 12 healthy adults. After administration of a single 150-mg oral dose of pirmenol on day 1, pirmenol plasma and urine concentrations were determined for 72 hours postdose. On days 4 through 17, subjects received 600 mg of rifampin once daily.

Multiple-dose cimetidine administration does not influence the single-dose pharmacokinetics of quinapril and its active metabolite (CI-928).

The potential effect of cimetidine on the pharmacokinetic profiles of quinapril and its active metabolite CI-928 was evaluated in eight healthy volunteers. Each subject received a single 40-mg quinapril dose on days 1 and 12 and cimetidine 300 mg four times daily on days 8 through 13. Serial blood and urine samples were collected for assay of quinapril and CI-928 concentrations.