Lipidomics and genomics in mental health: insights into major depressive disorder, bipolar disorder, schizophrenia, and obsessive-compulsive disorder.

Introduction: This systematic review explores the hypothesis that various lipid categories and lipid metabolism-related genomic variations link to mental disorders, seeking potential clinically useful markers.

Methods: We searched PubMed, Scopus, and PsycInfo databases until October 12th, 2024, using terms related to lipidomics, lipid-related genomics, and different mental disorders, i.e.

ADHD in adults and criminal behavior: The role of psychiatric comorbidities and clinical and sociodemographic factors in a clinical sample.

Introduction: ADHD is a neurodevelopmental disorder associated with functional, behavioral, and relational difficulties. Its onset is in childhood, before the age of 12, and it often persists into adulthood. This study investigates the link between ADHD in adulthood, psychiatric comorbidities, and the risk of criminal behavior, analyzing the impact of clinical and sociodemographic variables.

Unveiling the role of poly(vinyl alcohol) in the production of mucus-penetrating PLGA nanoparticles.

Mucosal drug delivery offers a promising non-invasive approach in pharmaceutical sciences but faces challenges from the protective mucus layer on mucosal surfaces, limiting drug absorption. Polymeric nanoparticles (NPs) have emerged as effective carriers, leveraging their small size to enhance mucus penetration and drug absorption. This study investigates polyvinyl alcohol (PVA)'s role in enhancing poly(lactic-co-glycolic acid) (PLGA) NPs for mucosal drug delivery.

Violence Against Healthcare Workers in a University Hospital of Central Italy: How Risk Management Interventions Can Help Change a Trend.

: Violence against workers (physical, verbal, or psychological abuse), even if it affects all professional categories, is up to ten times higher in healthcare workers. A University Hospital of Central Italy has gradually implemented a series of preventive measures, which might have impacted the trend of the phenomenon. : In order to monitor the episodes, an aggressive event reporting form was adopted throughout the hospital.

Investigating DRD2 and HTR2A polymorphisms in treatment-resistant schizophrenia: a comparative analysis with other treatment-resistant mental disorders and the healthy state.

This study investigates treatment-resistant schizophrenia (TRS) by analysing genetic markers in dopamine and serotonin receptors. Conducted on a cohort of 221 patients with treatment-resistant mental disorders, the research focused on DRD2 and HTR2A gene variants-specifically, rs1801028, rs6314, rs7997012, and rs6311. The findings suggest specific associations between certain genetic variants and TRS.