Neratinib Efficacy in Patients With EGFR Exon 18-Mutant Non-Small-Cell Lung Cancer: Findings From the SUMMIT Basket Trial.

Background: Activating mutations in the epidermal growth factor receptor (EGFR) gene occur in 7% to 23% of patients with non-small-cell lung cancer (NSCLC). A small proportion of these (3-5%) are exon 18 mutations. Neratinib, an irreversible pan-HER tyrosine kinase inhibitor (TKI), had activity in the phase II SUMMIT basket study.

YAP1 is a prognostic marker and its inhibition reduces tumor progression in adrenocortical tumors.

Background: Adrenocortical cancer (ACC) is rare and aggressive, with YAP1 overexpression associated with poor outcomes in pediatric patients. In this study, we investigated the mechanisms by which YAP1 drives ACC progression and explored it as a potential target therapy.

Methods: YAP1 expression and methylation in ACC were analyzed from pediatric and adult cohorts.

Adjuvant therapy in renal cell carcinoma (RCC): progress, at last.

In the United States, there is expected to be about 82,000 cases of renal cell carcinoma (RCC) in 2024. At diagnosis, approximately 65% of patients with RCC will have disease localized to the kidney. For decades, the standard of care for patients with localized RCC has been surgery, which is often curative, followed by radiographic surveillance.

Management Strategies for the Control of Diceraeus melacanthus (Dallas) in Soybean (Summer)-Maize (Fall/Winter) Successions.

The crop system of soybean (summer)-maize (fall/winter) succession has been adopted widely in the Neotropics. It inadvertently provides food to stink bugs between crops, forming "green-bridges," which favor Diceraeus melacanthus (Dallas) outbreaks. Attempts to control these outbreaks, usually occurring at the end of the soybean cycle and the beginning of the maize cycle, were made by spraying insecticides at the time of soybean desiccation in addition to insecticide seed treatment on maize, but apparently it has been insufficient to provide acceptable control.

Using Egg Parasitoids to Manage Caterpillars in Soybean and Maize: Benefits, Challenges, and Major Recommendations.

The use of egg parasitoids in Augmentative Biological Control (ABC) is a highly effective strategy within the integrated pest management (IPM) of lepidopteran defoliators. Safer than chemical insecticides, these natural antagonists have demonstrated significant efficacy. and , known for their high parasitism rates, are the most extensively used and studied parasitoids for controlling economically important lepidopterous in crops such as soybean and maize.