Publications by authors named "A B Bikhazi"
The mechanisms by which exendin-4 and selenium exert their antidiabetic actions are still unclear. Here, we investigated the effects of exendin-4 or selenium administration on the expression of glucagon-like peptide-1 receptor (GLP-1R), insulin receptor substrate-1 (IRS-1), and preproinsulin in the pancreas of diabetic rats. Diabetes was induced by streptozotocin administration.
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- * The research included seven groups of rats to analyze various treatments, with a focus on measuring ET-1 binding affinity and receptor densities in coronary endothelium and cardiomyocytes.
- * Findings showed that while exendin-4 normalized ET-1 receptor binding on the endothelium, aliskiren achieved this effect on cardiomyocytes, suggesting that aliskiren may help reduce blood vessel issues linked to type-1 diabetes.
Selenium and exendin-4 exert antidiabetic effects by unknown mechanisms. Herein, we investigated their effects on the expression of glucagon-like peptide-1 receptor (GLP-1R), insulin receptor substrate-1 (IRS-1), and Raf-1 in the livers of rats with streptozotocin-induced diabetes. Diabetic rats were injected intraperitoneally with exendin-4 (0.
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- This study investigates how long-term suppression of the renin-angiotensin system and incretin mimetic treatments affect GLP-1 receptor binding in heart tissues of type 1 diabetic rats.
- It involves several treatment groups, including normal rats and those treated with insulin, Exendin-4, Aliskiren, or combinations of these therapies.
- Findings indicate diabetes alters GLP-1 binding affinity in different heart tissues, with Exendin-4 combined with Aliskiren normalizing binding in the coronary endothelium, while Exendin-4 alone is most effective in cardiomyocytes.