[Assessment of dynamics of the autonomic cardiovascular system regulation based on low-frequency rhythm synchronization in patients with ischemic heart diseases complicated by myocardial infarction treated with metoprolol].

Aim: To develop a procedure for assessing the adequacy of metoprolol use in patients with coronary heart disease (CHD) on the basis of synchronization of 0.1-Hz rhythms in cardiac rhythm variability (CRV) and vascular blood filling in the microcirculatory bed (MCB). Materials and methods.

[The investigation of the synchronization between rhythms in the human cardiovascular system from time series of R-R-intervals].

We demonstrated that, from the sequence of R-R intervals, it is possible to calculate the instantaneous phases and instantaneous frequencies of the main rhythmic processes governing the cardiovascular dynamics in humans, namely, the main heart rhythm, respiration, and the process of slow regulation of blood pressure with basic frequency close to 0.1 Hz. For the cases of spontaneous respiration and paced respiration with a fixed frequency, the synchronization between the rhythms of the cardiovascular system was investigated based on the analysis of only the time series of R-R intervals.

[Prognostication of coronary atherosclerosis for selection of tactics of management of patients with ischemic heart disease].

Aim: To create an artificial neural network for prognostication of coronary atherosclerosis and thus selection of patients requiring invasive interventions.

Methods And Results: Efficacy of prognostication made by a physician and by a model was compared basing on probabilistic estimates with consideration of individual level of risk. Nineteen clinical and instrumental parameters were entered into multifactorial analysis.