Publications by authors named "A B Benchimol"
Aim: To assess the impact of the HbA1c levels achieved with antidiabetic therapies (ADTs) on the risk of MACE.
Methods: A systematic search was performed in PubMed, Cochrane, and ClinicalTrials. gov for RCTs published up to March 2022 reporting the occurrence of MACE and all-cause mortality in individuals with T2DM treated with all marketed ADTs, including a sample size ≥100 individuals in each study arm and follow-up ≥24 weeks.
Article Synopsis
- The study investigates the cardiovascular safety of bupropion, naltrexone, and their combination, as there is a lack of evidence despite their approval for clinical use.
- A meta-analysis of 12 randomized clinical trials included over 19,000 patients and found no significant association between these treatments and the occurrence of major cardiovascular adverse events (MACE).
- The statistical analysis showed a strong probability of validity, confirming that naltrexone, bupropion, or their combination do not increase the risk of MACE compared to a placebo.
The prevalence of obesity, pre-diabetes, and type 2 diabetes (T2D) is increasing worldwide, especially in the developing nations of South America. Brazil has experienced an exponential increase in the prevalence of these chronic non-communicable diseases. The rising prevalence is probably due to changing eating patterns, sedentary living, and a progressive aging of the population.
View Article and Find Full Text PDFType 2 diabetes (T2D) and prediabetes have a major global impact through high disease prevalence, significant downstream pathophysiologic effects, and enormous financial liabilities. To mitigate this disease burden, interventions of proven effectiveness must be used. Evidence shows that nutrition therapy improves glycemic control and reduces the risks of diabetes and its complications.
View Article and Find Full Text PDFBackground: Previously, we validated determination of ankle-brachial index using an automatic blood pressure device.
Aim: To test the feasibility and accuracy of the automatic method in assessing pathological ankle-brachial indexes in routine preventive examinations.
Methods: Two physicians enrolled 354 subjects (74% men) randomly for automatic ankle-brachial index measurements using an OMRON HM 722 device.