Publications by authors named "A Azmani"
Article Synopsis
- Traditional antibiotics are becoming less effective due to the rise of multidrug-resistant bacteria, largely driven by efflux pumps.
- A study screened 210 strains of Moroccan Actinobacteria to identify those producing efflux pump inhibitors, revealing 14 active isolates that inhibit a functional efflux system but not a mutant version.
- Focusing on four strains with the strongest inhibitory activity, researchers identified them taxonomically, suggesting their potential in developing new antibacterial treatments.
Article Synopsis
- Frontotemporal lobar degeneration (FTLD) is a diverse disorder with various pathological subtypes, including the newly identified FTLD-FUS, characterized by unique cellular inclusions and significant atrophy of the caudate nucleus.
- A study involving 387 patients with frontotemporal dementia identified only 4 cases of FTLD-FUS among 37 FTLD-U cases, highlighting its relatively low frequency but distinct clinical features.
- Key indicators for diagnosing FTLD-FUS include age of onset ≤40 years, a negative family history, and the presence of caudate atrophy detected through MRI, providing a predictive framework for this subtype of FTLD.
Background: Progressive supranuclear palsy (PSP) is a progressive neurodegenerative disorder characterized by aggregates of the microtubule-associated protein tau (MAPT). A nonsignificant trend for positive family history has been observed in two case-control studies and several pedigrees with familial clustering of parkinsonism have been described. Occasionally, mutations in MAPT are found in patients with a clinical phenotype similar to PSP.
View Article and Find Full Text PDFBackground: Frontotemporal dementia (FTD) is the second most common type of presenile dementia and can be distinguished into various clinical variants. The identification of MAPT and GRN defects and the discovery of the TDP-43 protein in FTD have led to the classification of pathologic and genetic subtypes. In addition to these genetic subtypes, there exist familial forms of FTD with unknown genetic defects.
View Article and Find Full Text PDFFrontotemporal dementia is accompanied by motor neuron disease (FTD + MND) in approximately 10% of cases. There is accumulating evidence for a clinicopathological overlap between FTD and MND based on observations of familial aggregation and neuropathological findings of ubiquitin-positive neuronal cytoplasmatic inclusions (NCI) in lower motor neurons, hippocampus and neocortex in both conditions. Several familial forms exist with different genetic loci and defects.
View Article and Find Full Text PDF