Publications by authors named "A Ayyagari"
A pilot study of a scalable training programme for coaches delivering webSTAIR.
Eur J Psychotraumatol
November 2024
Accessible, low-cost digital programmes are emerging as a means by which to address high rates of mental health problems. However, the development and assessment of scalable training programmes for effective use of digital interventions has lagged. This is particularly important, as coach-supported digital interventions provide benefits that substantially and consistently exceed those of programmes that are entirely self-guided.
View Article and Find Full Text PDFBackground: A novel adeno-associated virus 2 (AAV2)-carried multi-characteristic opsin (MCO) (MCO-010) is undergoing several clinical trials as a novel therapeutic modality for the treatment of degenerative retinal diseases including retinitis pigmentosa and Stargardt disease. The present study aimed to determine the ocular and systemic safety of MCO-010 and the AAV2 vehicle in adult Beagle dogs following intravitreal (IVT) injection.
Methods: The current safety/toxicology studies spanning 13 weeks described here utilized well-documented techniques to assess the effects of IVT injection of MCO-010 up to 2.
Article Synopsis
- Researchers developed solid lubricant coatings using TiCT-Graphene Oxide blends, which were spray-coated on bearing steel surfaces to enhance performance in industrial applications.
- Testing revealed these coatings significantly reduced friction to 0.065 at high pressures while also protecting against wear better than traditional single-component coatings.
- The performance was linked to the creation of a robust tribolayer during operation, as shown through various advanced microscopy and spectroscopy techniques, emphasizing the connection between the material's structure, properties, and processing.
Article Synopsis
- Researchers are working towards achieving superlubricity, or nearly zero friction, by applying a blend of TiCT and MoS as a lubricant on rough steel surfaces.
- Tests revealed that these nanocomposites could create superlubricious states, which had not previously been observed in either material alone under similar conditions.
- Advanced techniques like Raman spectroscopy and electron microscopy helped identify a robust tribolayer that contributed to impressive lubrication performance at high pressure and sliding speeds.