Synthesis of some substituted furan amino acid derivatives.

Some substituted furan amino acid derivatives were prepared from 5-bromo furoyl chloride and 5-nitrofuran acryloyl chloride. Some of the prepared compounds were found to be highly active against gram negative bacteria.

Effects of artemisinin, dihydroartemisinin and arteether on immune responses of normal mice.

Artemisinin (Qinghaosu) is a potent antimalarial sesquiterpene lactone isolated from the Chinese herb Artemisia annua. Arteether, a potent semisynthetic analogue of dihydroartemisinin is being developed by the World Health Organization as the artemisinin derivative of choice for the treatment of malaria. All three agents in doses of 400 and 600 mg/kg body weight were found to exhibit marked suppression of humoral responses, as measured by the hemolytic plaque assay, with arteether being the most potent.

The synthesis of 4-[(2-Hydroxy-4-quinolyl)methyl]-3,5-pyrazolidinediones and related products.

In the present work, the synthesis of 4-[(2-Hydroxy-4-quinolyl)methyl]-3,S-pyrazolidinediones and related compounds has been described.

The derivatives of 3-(1H-benzikmidazole-2) propanoic acid synthesis and analgetic and anti inflammatory activity.

Several derivatives of 3-(1H-benzimidazole-2) propanoic acid (Procodazol) were prepared using some aldehydes by the condensation reaction. The resulting products were lactam and acid derivatives. According to the spectral studies it was found that the hydrogen atoms of the 3-methylene group of 3-(1H-benzimidazole-2) propanoic acid take part in the reaction.