Publications by authors named "A Auclair"

Article Synopsis
  • Biotransformation is a crucial area within drug metabolism and pharmacokinetics that evaluates metabolites to ensure drug safety and compliance with regulatory guidelines.
  • Metabolite identification (metID) scientists use various strategies to identify human metabolites early in drug development and assess exposure risks, following guidelines like the Metabolites in Safety Testing (MIST).
  • A survey involving 26 pharmaceutical companies aimed to evaluate the effectiveness of current in vitro metID practices in predicting human metabolites, highlighting the need for a standardized framework and looking toward future advancements.
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Background: We aimed to determine whether the addition of yoga to a regular exercise training regimen improves cardiometabolic risk profile.

Methods: Sixty individuals with diagnosed hypertension (≥ 140/90 mm Hg for 3 measurements on different days) were recruited in an exercise training program. In addition to aerobic exercise training, participants were randomised into either a yoga or a stretching control group.

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Purpose: To assess the impact of bariatric surgery and an added supervised exercise training programme on heart rate variability (HRV) in patients with severe obesity.

Methods: Fifty-nine patients who underwent bariatric surgery were randomised in the post-operative period to a 12-week supervised exercise training programme (moderate intensity combination aerobic/resistance exercise training programme) or a control group. Indices of HRV including time-domain, spectral-domain, and nonlinear parameters were measured preoperatively, and at 3, 6, and 12 months.

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Background: Exaggerated blood pressure response to exercise is a cardiovascular risk factor associated to higher morbidity and mortality. Severely obese patients have an increased risk of exercise-induced hypertension (EIH). We aimed to assess the blood pressure response to exercise in patients with severe obesity who underwent bariatric surgery as well as the main determinants of this response.

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