Publications by authors named "A Atenhan"
Article Synopsis
- Dupilumab is used for severe type 2 asthma, but patient characteristics in real-world settings are not fully understood, prompting this study to examine baseline data from the ProVENT study.
- In the analysis of 99 patients (59% females), key findings include a median age of 54 and a prevalence of adult-onset asthma (58%) and allergic phenotype (48%), with notable inflammatory markers such as FeNO and eosinophil counts.
- The study found diverse profiles among patients: 70% met at least one GINA criterion for airway inflammation, with 64% having T2-related comorbidities, indicating that eligibility for dupilumab treatment encompasses a range of clinical and biochemical
Corrigendum: Is the humoral immunity dispensable for the pathogenesis of psoriasis?
J Eur Acad Dermatol Venereol
December 2019
Is the humoral immunity dispensable for the pathogenesis of psoriasis?
J Eur Acad Dermatol Venereol
January 2019
Background: Imbalances of T-cell subsets are hallmarks of disease-specific inflammation in psoriasis. However, the relevance of B cells for psoriasis remains poorly investigated.
Objective: To analyse the role of B cells and immunoglobulins for the disease-specific immunology of psoriasis.
Background: A standardized human model to study early pathogenic events in patients with psoriasis is missing. Activation of Toll-like receptor 7/8 by means of topical application of imiquimod is the most commonly used mouse model of psoriasis.
Objective: We sought to investigate the potential of a human imiquimod patch test model to resemble human psoriasis.
Background: The main function of sebocytes is considered to be the production of lipids to moisturize the skin. However, it recently became apparent that sebocytes release chemokines and cytokines and respond to proinflammatory stimuli as well as the presence of bacteria.
Objectives: To analyse the functional communication between human sebocytes and T cells.