Publications by authors named "A Astrup"
Article Synopsis
- The study explores the genetic factors influencing β-cell function (BCF) and their relationship to type 2 diabetes (T2D), expanding on previous genetic research using large-scale data.
- By analyzing GWAS data from around 26,000 individuals, the researchers identified 55 unique genetic associations related to BCF traits derived from oral glucose tolerance tests.
- The findings reveal key genes that regulate insulin secretion and illustrate how different genetic mechanisms can affect T2D risk, offering a deeper understanding of the complex biology behind the disease.
Application of the physical laws of energy and mass conservation at the whole-body level is not necessarily informative about causal mechanisms of weight gain and the development of obesity. The energy balance model (EBM) and the carbohydrate-insulin model (CIM) are two plausible theories, among several others, attempting to explain why obesity develops within an overall common physiological framework of regulation of human energy metabolism. These models have been used to explain the pathogenesis of obesity in individuals as well as the dramatic increases in the prevalence of obesity worldwide over the past half century.
View Article and Find Full Text PDFThe New Nordic Renal Diet (NNRD) is a whole-food approach, tailored to meet recommended guidelines in patients with moderate chronic kidney disease (stage 3b-4). The NNRD improved various metabolic and physiological endpoints during a 26-week randomized controlled study. Here, we examined the effect of dietary intervention on health-related quality of life (HRQoL).
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- Behavioral weight loss programs are effective in reducing health risks and improving outcomes, but long-term data on their impact is limited, prompting this large study with over 10,000 participants to evaluate a specific nutritional and psycho-behavioral rehabilitation program (RNPC).
- The study is conducted across 92 centers in France and will analyze various data points, including health conditions, medication use, and sleep-related measures over a span of two years, with follow-ups lasting up to five years.
- Ethical approval has been obtained, and study findings will be published in peer-reviewed journals and presented at conferences, potentially shaping future research on the RNPC's effectiveness.
Introduction: Obesity adversely affects the health of the individual and impacts society through increased healthcare costs and lost workdays. Individuals in lower socioeconomic groups are more severely affected. Here, we examined people living with severe obesity and comorbidities across educational levels.
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