Publications by authors named "A Ashida"
Daptomycin, an anti-methicillin-resistant Staphylococcus aureus drug, causes exposure-dependent muscle toxicity and eosinophilic pneumonia. Although the area under the concentration-time curve (AUC)-guided dosing is crucial, an optimal blood sampling strategy is lacking. This study aimed to identify an optimal limited sampling strategy using Bayesian forecasting to rapidly achieve the target AUC.
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- Maturity-onset diabetes of the young 1 (MODY1) is linked to large birth size and temporary low blood sugar in newborns, with a specific genetic mutation leading to more severe complications like Fanconi syndrome (FS).
- In a reported case, a patient was diagnosed with MODY1 due to abnormal kidney mitochondria found through electron microscopy before diabetes symptoms appeared, highlighting the complexity of the condition.
- Genetic testing later confirmed a pathogenic variant in the HNF4A gene, suggesting that mitochondrial dysfunction plays a crucial role in the development of both MODY1 and FS in this patient.
Objective: This study explored the predictors of abemaciclib discontinuation, a cyclin-dependent kinase 4 and 6 inhibitor, in patients with breast cancer.
Material And Methods: Between November 2018 and March 2023, 147 patients with breast cancer treated with abemaciclib at Osaka Medical and Pharmaceutical University Hospital and Kindai University Nara Hospital were included. The exclusion criteria were as follows: lack of blood testing within 2 weeks prior to starting abemaciclib therapy, transfer to another facility after the commencement of abemaciclib therapy, and discontinuation of abemaciclib therapy due to the diagnosis of another cancer.
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- The study investigates the relationship between amenamevir, a new anti-herpesvirus drug, and the risk of encephalopathy, a potential complication during herpes zoster treatment.
- Using data from the Japanese Adverse Drug Event Report (JADER) database, the researchers identified 246 patients treated with amenamevir and found a significant association between the drug and encephalopathy, with older age being a key risk factor.
- The findings highlight the need for healthcare providers to monitor elderly patients (especially those aged 70 and above) closely for signs of encephalopathy when prescribing amenamevir.
species are endophytic fungi that systemically colonize grass species. Here, we report the genome sequences of strains HS and DP isolated for the first time from in Nagoya, Japan.
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