Androgens Modulate the Immune Profile in a Mouse Model of Polycystic Ovary Syndrome.

Polycystic ovary syndrome (PCOS) is associated with a low-grade inflammation, but it is unknown how hyperandrogenism, the hallmark of PCOS, affects the immune system. Using a PCOS-like mouse model, it is demonstrated that hyperandrogenism affects immune cell populations in reproductive, metabolic, and immunological tissues differently in a site-specific manner. Co-treatment with an androgen receptor antagonist prevents most of these alterations, demonstrating that these effects are mediated through androgen receptor activation.

The role of B cells in immune cell activation in polycystic ovary syndrome.

Variations in B cell numbers are associated with polycystic ovary syndrome (PCOS) through unknown mechanisms. Here, we demonstrate that B cells are not central mediators of PCOS pathology and that their frequencies are altered as a direct effect of androgen receptor activation. Hyperandrogenic women with PCOS have increased frequencies of age-associated double-negative B memory cells and increased levels of circulating immunoglobulin M (IgM).

Effect of Whey Proteins on Malnutrition and Extubating Time of Critically Ill COVID-19 Patients.

Unlabelled: The novel SARS-CoV-2 virus has led to a severe pandemic, starting from early 2020. Intensive care (ICU) management of the COVID-19 disease is difficult with high morbidity and mortality. Early nutritional support, especially with whey protein, seems to be crucial in this medical case.

Mobility in times of pandemics: Evidence on the spread of COVID19 in Italy's labour market areas.

We investigate the interplay between the local spread of COVID-19 and patterns of individual mobility within and across self-contained geographical areas. Conceptually, we connect the debate on regional development in the presence of shocks with the literature on spatial labour markets and address some research questions about the role of individual mobility in affecting the spread of the disease. By looking at granular flows of Facebook users moving within and across Italian labour market areas (LMAs), we analyse whether their heterogeneous internal and external mobility has had a significant impact on excess mortality.

The geography of COVID-19 and the structure of local economies: The case of Italy.

The aim of this article is to analyze the subnational spread of COVID-19 in Italy using an economic geography perspective. The striking spatial unevenness of COVID-19 suggests that the infection has hit economic core locations harder, and this raises questions about whether, and how, the subnational geography of the disease is connected to the economic base of localities. We provide some first evidence consistent with the possibility that the local specialization in geographically concentrated economic activities acts as a vehicle of disease transmission.