Publications by authors named "A Arce-Sillas"
Increased levels of regulatory T cells and IL-10-producing regulatory B cells are linked to improved clinical outcome in Parkinson's disease: a 1-year observational study.
J Neural Transm (Vienna)
August 2024
Whilst the contribution of peripheral and central inflammation to neurodegeneration in Parkinson's disease and the role of the immune response in this disorder are well known, the effects of the anti-inflammatory response on the disease have not been described in depth. This study is aimed to assess the changes in the regulatory/inflammatory immune response in recently diagnosed, untreated PD patients and a year after. Twenty-one PD patients and 19 healthy controls were included and followed-up for 1 year.
View Article and Find Full Text PDFBackground: Neuroinflammation has been proved to play a role in dopaminergic neuronal death in Parkinson's disease (PD). This link highlights the relevance of the immune response in the progression of the disease. However, little is known about the impact of peripheral immune response on the disease.
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- Murine cysticercosis serves as a model for studying human neurocysticercosis, with genetic and immune differences influencing susceptibility in mouse strains.
- The study focuses on T regulatory cells (Tregs) and their role in parasite establishment, comparing responses in susceptible BALB/cAnN and non-susceptible C57BL/6 mice.
- Findings suggest that higher Treg levels in BALB/cAnN mice aid in parasite survival, while non-susceptible strains may rely on Tregs for immune balance rather than infection support.
Rare conditions showing psychiatric symptoms and movement disorders have been linked with the presence of anti-glutamate decarboxylase antibodies. Proinflammatory and antiinflammatory immune responses were assessed in patients with neurological disorders associated to anti-glutamic acid decarboxylase antibodies (NDGAD). Immunoregulatory and proinflammatory cell populations were quantified by flow cytometry.
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- The flatworm Taenia solium causes cysticercosis in humans and pigs, leading to a serious condition called neurocysticercosis, particularly in rural areas of Mexico and other developing countries.
- This study focuses on identifying and characterizing proteins secreted by T. solium cysticerci from infected pigs using advanced proteomic techniques.
- The research identified 108 conserved and 186 differential proteins, including 14 potentially vaccine-targeting proteins, and revealed a link between the parasite's signaling pathways and human cancer, along with the novel mechanism of protein release via exosome-like structures.