Publications by authors named "A Anzulovich"
Late-Onset Caloric Restriction Improves Cognitive Performance and Restores Circadian Patterns of Neurotrophic, Clock, and Epigenetic Factors in the Hippocampus of Old Male Rats.
J Gerontol A Biol Sci Med Sci
December 2024
Article Synopsis
- Aging leads to functional decline and cognitive impairment, but caloric restriction (CR) can help delay these effects and improve cognitive function in older adults.
- There is a connection between memory, learning, and the circadian clock, which indicates that timing and regulation are essential for cognitive processes.
- Research showed that late-onset CR restored circadian rhythms and improved cognitive abilities in aging rats, suggesting that lifestyle changes like CR could preserve brain health as we age.
Aging abolishes circadian rhythms and disrupts temporal organization of antioxidant-prooxidant status, endogenous clock activity and neurotrophin gene expression in the rat temporal cortex.
Neuroscience
November 2024
Disruption of circadian rhythms contributes to deficits in cognitive functions during aging. Up to date, the biochemical, molecular and chronobiological bases of such deterioration have not been completely elucidated. Here, we aim: 1) to investigate the endogenous nature of 24 h-rhythms of antioxidant defenses, oxidative stress, clocḱ's, and neurotrophic factors expression, in the rat temporal cortex (TC), and 2) to study the consequences of aging on the circadian organization of those factors.
View Article and Find Full Text PDFCircadian organization of clock factors, antioxidant defenses, and cognitive genes expression, is lost in the cerebellum of aged rats. Possible targets of therapeutic strategies for the treatment of age-related cerebellar disorders.
Brain Res
December 2024
Aging is a major risk factor for cognitive deficits, impaired locomotion, and gait disorders. Although oxidative stress and circadian disruption are involved in both normal aging and the pathogenesis of age-associated diseases, just a very few studies explore the consequences of aging on circadian rhythms in the cerebellum. Here, we investigated age-dependent changes in the circadian organization of the molecular clock, antioxidant defenses and synaptic plasticity-related factors, in the rat cerebellum, and discussed the impact of that altered temporal organization on the cognitive function of this brain area.
View Article and Find Full Text PDFAlzheimer's dementia (AD) is a neurodegenerative disorder that causes memory loss and dementia in older adults. Intracellular accumulation of Aβ causes an imbalance in the oxidative status and cognitive dysfunctions. Besides oxidative stress and loss of memory, Alzheimer's patients show dysfunction of the circadian rhythms.
View Article and Find Full Text PDFIntroduction: Epilepsy is closely related to daily rhythms, such as the sleep-wake cycle. The objective of this study was to evaluate the relationship between drug-resistant temporal lobe epilepsy (TLE) and the parameters related to the sleep-wake cycle, seizure time and epilepsy laterality.
Methods: Consecutive patients admitted to the video electroencephalogram unit with a diagnosis of TLE were enrolled.