Influence of the plant extract complex "AdMax" on global gene expression levels in cultured human fibroblasts.

Ethanol/water extracts from roots of Leuzea carthamoides Iljin, Rhodiola rosea L., Eleutherococcus senticosus Maxim, and from dry berries of Schizandra chinensis Baill. are known as adaptogenic remedies, which enhance physical endurance, counteract fatigue and restore suppressed immunity.

Analysis of effects of the herbal preparation Circulat on gene expression levels in cultured human fibroblasts.

Circulat is a systemic standardized plant extract formulation that was developed for the prevention of severe manifestations of type 2 diabetes such as necrotic damage of the plantar foot. With the aim of revealing the molecular mechanisms underlying Circulat's biological activity, the effects of Circulat treatment on gene expression levels were examined in the cultured human fibroblast cell line MRC-5 using Affymetrix oligonucleotide microarrays. The analysis identified 187 genes, the expression levels of which underwent significant changes upon Circulat treatment.

Physiological model of the stimulative effects of alcohol in low-to-moderate doses.

A physiological model of alcohol use is proposed, based on the observation that ethanol is a natural intracellular metabolite. It is suggested that ethanol synthesis is an intermediate step in the metabolic pathway of elimination of the excess of energy-releasing substrates from mitochondria and the cytosol when the cell does not require additional energy. The process is first of all important for elimination of acetyl-CoA from mitochondria.

Indications of changed amino acid homeostasis in untreated and treated PKU.

Amino acid patterns were investigated in children with untreated and treated phenylketonuria (PKU) and compared with a hospitalized paediatric control group. Correlation ratios, i.e.