Fingolimod, a sphingosine-1-phosphate receptor modulator, prevents neonatal bronchopulmonary dysplasia and subsequent airway remodeling in a murine model.

Neonatal bronchopulmonary dysplasia (BPD) is associated with alveolar simplification and airway remodeling. Airway remodeling leads to deformation of airways characterized by peribronchial collagen deposition and hypertrophy of airway smooth muscle, which contribute to the narrowing of airways. Poorly developed lungs contribute to reduced lung function that deteriorates with the passage of time.

Development and validation of molnupiravir assessment in bulk powder and pharmaceutical formulation by the RP-HPLC-UV method.

An accurate, sensitive and selective RP-HPLC-UV method has been established for the estimation of Molnupiravir (MOL) in pure bulk powder and pharmaceutical formulation. Separation was achieved on an Inertsil C column (150.0 mm × 4.

Simultaneous determination of Avanafil and Dapoxetine in human plasma using liquid chromatography/tandem mass spectrometry (LC-MS/MS) based on a protein precipitation technique.

A rapid and selective LC-MS/MS method is described for the simultaneous assay of Avanafil and Dapoxetine in human plasma a protein precipitation (PP) sample preparation technique. Tadalafil was chosen as the internal standard reaching good recovery and reproducibility while diminishing the effects of the matrix. An Agilent Zorbax Eclipse XDB C column (4.

Excellent Capacitor-Varistor Properties in Lead-Free CaCuTiO-SrTiO System with a Wrinkle Structure via Interface Engineering.

Lead-free perovskite CaCuTiO (CCTO) dielectrics are extremely important candidates for capacitor-varistor dual-function materials. However, their overall success in applications is somewhat controlled by the longstanding issues such as relatively large dielectric loss and insufficiently high electric breakdown field. Herein, we report the success in the preparation of an optimized lead-free (1-)CaCuTiO-SrTiO (CCTO-STO) composite system with improved dielectric and nonlinear properties via interface engineering.

New Transparent Magnetic Semiconductor NiCuI which Can Perform as Either P-type or N-type and Success in the P-N Homojunction Diode.

A semiconductor that can be doped to be either p-type or n-type is of great importance, as p-n homojunctions are desirable for realizing various electronic devices and processes. However, because of pervasive doping asymmetry for wide band gap semiconductors, the achievement of both p-type and n-type in a single wide gap material is very difficult. Here, we report the success in developing a new transparent magnetic NiCuI halide semiconductor that can be either p-type or n-type depending on Ni fraction in NiCuI.