Publications by authors named "A Andrzejewski"
Single-molecule fluorescence resonance energy transfer (smFRET) is a powerful technique for studying the structural dynamics of protein molecules or detecting interactions between protein molecules in real time. Due to the high sensitivity in spatial and temporal resolution, smFRET can decipher sub-populations within heterogeneous native state conformations, which are generally lost in traditional measurements due to ensemble averaging. In addition, the single-molecule reconstitution allows protein molecules to be observed for an extensive period of time and can recapitulate the geometry of the cellular environment to retain biological function.
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- Research revealed a total of 1766 ocular tuberculosis (OTB) cases in the US from 1993 to 2019, making up 1.6% of all extrapulmonary tuberculosis (EPTB) cases, with a significant increase observed during the last decade.
- Patients with OTB were generally older, more likely to be US-born, and had higher rates of diabetes compared to those with other EPTB forms, while being less frequently HIV positive.
- OTB cases were often not lab confirmed, primarily relied on interferon gamma release assay tests for diagnosis, and highlighted the need for further research to improve understanding and treatment of OTB.
2-ethylhexanol, an oxo alcohol competitively priced on the global market, has not been explored intensively as a raw material for surfactants, due to its weak hydrophobic character. However, its sequenced propoxylation and ethoxylation yield an innovative amphiphilic structure, which exhibits unique interfacial activity. The paper presents the differences in the fractional composition of innovative surfactants derived from 2-EH alcohol prepared using alkali and dimetalcyanide catalysts, as well as examples of excellent adsorption and interfacial properties of the latter.
View Article and Find Full Text PDFNeurotransmitter release of synaptic vesicles relies on the assembly of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex, consisting of syntaxin and SNAP-25 on the plasma membrane and synaptobrevin on the synaptic vesicle. The formation of the SNARE complex progressively zippers towards the membranes, which drives membrane fusion between the plasma membrane and the synaptic vesicle. However, the underlying molecular mechanism of SNARE complex regulation is unclear.
View Article and Find Full Text PDFBackground: Multiple epiphyseal dysplasia (MED) and pseudoachondroplasia (PSACH) are congenital skeletal disorders characterized by irregular epiphyses, mild or severe short stature and early-onset osteoarthritis which frequently affect the hips. The current study evaluates the long-term results of the Chiari osteotomy in MED and PSACH patients.
Methods: Twenty patients (14 MED and 6 PSACH) were retrospectively included.