Publications by authors named "A Andreis"
: the role of the R202Q (c.605G>A, p.Arg202Gln) missense variant of the MEFV gene has been debated as either a benign polymorphism or a potentially pathogenic mutation.
View Article and Find Full Text PDFEchocardiographic and clinical features of patients developing prosthesis-patient mismatch after transcatheter aortic valve replacement: Insights from the Recovery-TAVR registry.
Am Heart J
September 2024
Article Synopsis
- The study investigates the prevalence and impact of prosthesis-patient mismatch (PPM) in patients undergoing transcatheter aortic valve replacement (TAVR) on heart damage and mortality.
- A cohort of 963 patients was analyzed, revealing that 18% experienced PPM post-TAVR, with 7.7% having severe cases.
- Those with PPM exhibited significant heart changes after one year, including increased left ventricle size and more paravalvular aortic regurgitation compared to those without PPM.
Background: Diagnosis of pericarditis may be challenging because not all patients meet the conventional criteria. An overlooked diagnosis implies a longer course of symptoms and an increased risk of recurrences. C-reactive protein (CRP), widely used as an inflammation marker, has some limitations.
View Article and Find Full Text PDFAim: Anakinra, an anti IL-1 agent targeting IL-1 alfa and beta, is available for the treatment of recurrent pericarditis in cases with corticosteroid dependence and colchicine resistance after failure of conventional therapies. However, it is unclear if the combination with colchicine, a non-specific inhibitor of the inflammasome targeting the same inflammatory pathway of IL-1, could provide additional benefit to prevent further recurrences. The aim of the present observational study is to assess whether the addition of colchicine on top of anakinra could prolong the time to first recurrence and prevent recurrences better than anakinra alone.
View Article and Find Full Text PDFObjective: Clinical trials have evaluated the efficacy and safety of colchicine only in simple pericarditis, excluding cases of concomitant myocarditis. The aim of this paper is to evaluate the efficacy and safety of colchicine for the treatment of the first attack of acute pericarditis with concomitant myocardial involvement.
Methods: Double-centre retrospective cohort study analysing consecutive patients admitted for first attack of pericarditis with myocarditis and treated with or without colchicine.