Publications by authors named "A Andoh"
Background And Aims: While biologic therapy has revolutionized the treatment of Crohn's disease (CD), surgery remains unavoidable in cases involving ileal complications. We aimed to evaluate the efficacy of biologics on proximal ileal lesions using balloon-assisted enteroscopy (BAE).
Methods: This open-label multicenter prospective study was conducted at tertiary referral centers in Japan.
Background: Interleukin (IL)-23 is involved in the pathogenesis of ulcerative colitis (UC). A genome-wide significant association between IL23R p.G149R (rs76418789) and UC was previously identified in Japan and Korea.
View Article and Find Full Text PDFBackground: This registry aims to allow for a prospective non-interventional observational study of ulcerative colitis. This will facilitate monitoring of the current state of ulcerative colitis in Japan and improving the long-term disease course and adverse events associated with current treatment options.
Methods: Inclusion of patients from five centres in Japan is planned.
Article Synopsis
- Dysbiosis in the intestinal microflora is linked to inflammatory bowel disease (IBD), and this study explores the role of secreted IgA in regulating gut bacteria, particularly focusing on the effectiveness of mouse monoclonal IgA.
- Researchers sorted IgA-bound and unbound bacteria from IBD patients to analyze the interactions between IgA and gut microbiota, using advanced sequencing techniques and testing on gnotobiotic mice.
- The findings indicate that human IgA in IBD patients has abnormal binding patterns, while mouse IgA shows potential to bind and inhibit harmful gut bacteria, leading to a reduction in inflammation and improvement in microbiota imbalances.
Article Synopsis
- Endoscopic ultrasound shear wave elastography (EUS-SWE) is an effective method for evaluating pancreatic stiffness and diagnosing early chronic pancreatitis (ECP), a condition that hasn't been thoroughly researched yet.
- The study involved 657 patients, with 22 selected for each ECP and normal groups, finding that pancreatic stiffness was significantly higher in the ECP group (2.31 m/s) compared to the normal group (1.59 m/s).
- EUS-SWE showed strong diagnostic accuracy for ECP, with a cutoff value of 2.24 m/s linked to various EUS findings, confirming its potential as an objective tool in diagnosing ECP based on the Japanese diagnostic criteria from 2019.