Effects of the IL6 -174G>C promoter polymorphism and IL-6 serum levels on the progression of cutaneous malignant melanoma.

Cutaneous malignant melanoma (CMM) is one of the most immunogenic types of cancer, with a 6-fold higher rate of spontaneous regression than any other malignancy. In addition to responsiveness to different immunotherapies, the immunogenicity of CMM highlights the important role of the host immune system in the response to CMM. The present study aimed to explore the role of two functional promoter polymorphisms [ -174G>C (rs1800785) and -308G>A (rs1800629)] in the regulation of the genes encoding the pro-inflammatory cytokines interleukin (IL)-6 and tumor necrosis factor-α, specifically in patients with CMM.

Association of the MMP7 -181A>G Promoter Polymorphism with Early Onset of Chronic Obstructive Pulmonary Disease.

Chronic obstructive pulmonary disease (COPD) is characterized by decreased air flow and is associated with abnormal chronic inflammation in the airways and extensive tissue remodeling. Matrix metalloproteinase-7 (MMP7) is produced primarily by the epithelium of many organs, including the lungs. A functional MMP7 -181A>G (rs11568818) promoter polymorphism influences the binding of nuclear regulatory proteins modulating the transcription of the gene.

[Experience in diagnostic-therapeutic broncho-fibroscopy with children under combined general anesthesia].

An alternative method of bronchoscopy conduction under combined general anesthesia without artificial pulmonary ventilation usage was elaborated and substantiated in the patients ageing from 3 mo to 15 yrs old. In 40 patients, using rigid bronchoscope, it was possible to look over down to the order I bronchi only. There was observed the striated body muscles fibrillation after injection of myorelaxants and in 13 (86.

[Weight and chemical makeup of the liver of geese during fattening].

Experiments were carried out with regard to certain changes in the liver of geese during their fattening period. The observations were made before the fattening of the geese, namely on the 5th , 10th, 15th, 20th, 25th and 33rd days of the fattening. It was established that during the fattening period the weight of the liver was constantly increasing, especially between the 20th and 25th days.