Chlorhexidine-loaded microneedles for treatment of oral diseases.

Chlorhexidine (CHX) is a gold standard therapeutic agent against clinical oral pathogens. However, its oral use is limited due to unpleasant taste, alteration in taste buds, staining of teeth and mucous membranes. Therefore, CHX-loaded PLGA microneedles (MNs) were fabricated for local and controlled release in the oral cavity, using a casting mold method.

Effects of a 40-min nap on performance following evening exercise before, during, and after Ramadan fasting.

This study examined the effect of a 40-min nap (N40) the day after a night session of the Loughborough Intermittent Shuttle Test (LIST), before, during and after Ramadan. In a randomized crossover design, fifteen male soccer players completed the LIST in the evening (2100h), followed by either a N40 or no nap (N0) the next day, at 1400h. Performance on the 5-m shuttle run test (5mSRT), digit cancellation test (DCT), and subjective measures (i.

Efficacy of thyme honey in the management of oral aphthous ulcers: A randomized controlled clinical trial.

The current study aimed to assess the effect of thyme honey on pain relief in patients with minor aphthous ulcers as a primary objective, its healing effect on ulcer size reduction, and the Oral Health Impact Profile (OHIP-14). In this randomized clinical trial, 30 patients (15 in each group) having minor aphthous ulcers at the oral diagnostic clinic at the British University in Egypt were treated with either thyme honey or triamcinolone acetonide in orabase. Different clinical parameters were recorded for both groups at various intervals, such as pain intensity using the Visual Analog Scale (VAS), size of ulcers in mm, and OHIP-14.

A meta-analysis assessing reliability of the Yale Food Addiction Scale: Implications for compulsive eating and obesity.

Food addiction (FA) is linked to eating disorders and obesity. The Yale Food Addiction Scale (YFAS), which has various versions in different languages, is widely used to assess FA worldwide. This meta-analysis aimed to assess the YFAS through reliability generalization meta-analysis (REGEMA).

Conduction system pacing versus biventricular pacing in heart failure with reduced ejection fraction and electrical dyssynchrony.

Biventricular pacing (BiVP) has been the cornerstone of cardiac resynchronization therapy (CRT) in the management of symptomatic heart failure patients with reduced ejection fraction (HFrEF) and electrical dyssynchrony despite guideline-directed medical therapy (GDMT). However, BiVP has some limitations, including technical difficulties and high non-response rates. Conduction system pacing encompassing His bundle pacing (HBP) and left bundle branch area pacing (LBBAP) has recently emerged as a promising alternative to CRT in this group of patients.