Publications by authors named "A Ammann"
Introduction: Previous literature suggests that sphingolipids may impact systemic coagulation and platelet aggregation, thus modulating the risks of thrombotic events. The goal of this investigation was to evaluate the role of serum sphingolipids on intrinsic platelet function to assess whether pharmacologic manipulation of sphingolipid metabolites would impact platelet aggregability.
Methods: C57BL/6J mice were injected with either normal saline, 1 mg/kg FTY720 (synthetic sphingosine-1-phosphate [S1P] receptor analog), or 5 mg/kg SLM6031434 (sphingosine kinase two inhibitor).
Article Synopsis
- In April 2023, the National Comprehensive Cancer Network recommended neoadjuvant immunotherapy for certain patients with nonmetastatic mismatch repair deficient colon cancer, a subtype that comprises about 15% of colon cancers and responds well to immune treatments.
- A review of the literature identified 8 relevant studies out of 7691, focusing on safety and efficacy of this treatment, which included diverse agents and treatment durations.
- Results showed high rates of complete surgical resection (98%-100%) and significant pathological response rates (50%-91% achieving ypT0N0), with manageable safety profiles as most adverse events were mild to moderate.
Introduction: Grade-C postoperative pancreatic fistulas (POPFs) are dreaded complications following pancreaticoduodenectomy. The aim of this study was to quantify the incidence and risk factors associated with grade C POPF in a national database.
Methods: The National Surgical Quality Improvement Program targeted user files were queried for patients who underwent elective pancreaticoduodenectomy (2014-2020).
Background: The aim of this study was to examine sex differences in academic rank and productivity among members of the American Society of Transplant Surgeons in the United States.
Methods: Cross-sectional, focusing on current board-certified abdominal transplant surgeons in the United States. Demographic factors such as sex, region, and faculty rank were collected from institutional websites.
Breast infections are common, affect women of all ages, and are associated with significant morbidity. Despite overall prevalence, treatment varies significantly based on provider or institution and no central treatment guidelines exist to direct the management of breast infections. This article provides a summary of the current trends in management of breast infections.
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