Publications by authors named "A Amitrano"
Article Synopsis
- Human mesenchymal stem cells (hMSCs) react to mechanical stimuli like stiffness and fluid viscosity, which impacts their behavior.
- In environments with high fluid viscosity, hMSCs favor an osteogenic (bone-forming) phenotype over an adipogenic (fat-forming) one by altering their actin structure and enhancing cellular activities.
- This research highlights fluid viscosity as an important factor that not only influences hMSC differentiation but also encourages a more immunosuppressive M2 macrophage phenotype.
Article Synopsis
- Cells in confined spaces face mechanical challenges that impact their migration, but the exact effects on their migration machinery are not fully understood.
- Research shows that a protein called anillin, which regulates cytokinesis, is retained in the cytoplasm during interphase and is recruited to the edges of cells when they migrate in confined environments.
- Anillin works alongside another protein, Ect2, to enhance muscle contractility inside cells, which is crucial for effective invasion and movement in cancer progression.
Introduction: Sensorineural hearing loss (SNHL) has been suggested to be possibly related to congenital toxoplasmosis (CT), although its prevalence varies from 0% to 26%. This variance appears to be dependent especially on early timing of treatment. However, the available data are based on outdated studies conducted on small groups of patients that lack homogeneity.
View Article and Find Full Text PDFActivation effects on the physical characteristics of T lymphocytes.
Front Bioeng Biotechnol
May 2023
The deformability of leukocytes is relevant to a wide array of physiological and pathophysiological behaviors. The goal of this study is to provide a detailed, quantitative characterization of the mechanical properties of T cells and how those properties change with activation. We tested T cells and CD8 cells isolated from peripheral blood samples of healthy donors either immediately (naïve population) or after 7 days of activation .
View Article and Find Full Text PDFAdoptive transfer of genetically engineered chimeric antigen receptor (CAR) T cells is becoming a promising treatment option for hematological malignancies. However, T cell immunotherapies have mostly failed in individuals with solid tumors. Here, with a CRISPR-Cas9 pooled library, we performed an in vivo targeted loss-of-function screen and identified ST3 β-galactoside α-2,3-sialyltransferase 1 (ST3GAL1) as a negative regulator of the cancer-specific migration of CAR T cells.
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